Am J Physiol Gastrointest Liver Physiol 2018 02 26;314(2):G223-G230. Epub 2017 Oct 26.
UMR PNCA, AgroParisTech, INRA, Université Paris Saclay , Paris , France.
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Gastroenterology 2015 Dec 29;149(7):1910-1919.e5. Epub 2015 Aug 29.
CNRS-Aix-Marseille Université-UMR7282 Enzymology at Interfaces and Physiology of Lipolysis, Marseille, France. Electronic address:
Background & Aims: Pancreatic exocrine insufficiency (PEI) reduces pancreatic secretion of digestive enzymes, including lipases. Oral pancreatic enzyme replacement therapy (PERT) with pancreatin produces unsatisfactory results. The lipase 2 produced by the yeast Yarrowia lipolytica (YLLIP2; GenBank: AJ012632) might be used in PERT. Read More
Arch Anim Nutr 2015 18;69(2):98-112. Epub 2015 Feb 18.
a Institute for Animal Nutrition , University of Veterinary Medicine Hannover, Foundation , Hannover , Germany.
The pancreatic duct-ligated minipig (PL) is an established model of pancreatic exocrine insufficiency (PEI) with a significant decrease of nutrient digestibility. This study aimed to quantify and compare endogenous losses of nitrogen (N) (ileal and faecal) in minipigs receiving an almost N-free diet. Altogether, 12 Göttingen minipigs (7 PL and 5 control animals) fitted with an re-entrant ileo-caecal fistula were used. Read More
Clin Nutr 2011 Dec 8;30(6):831-7. Epub 2011 Jul 8.
Gastroenterology Unit, CRNH IdF, AP-HP, University Paris 13, Hôpital Avicenne, Bobigny, France.
Background & Aims: Pancreatic exocrine insufficiency (PEI) impairs fat absorption, but few data are available on protein absorption. We investigated this question in patients with chronic pancreatitis, both in the absence and presence of enzyme therapy, using a stable isotope sensitive method.
Methods: Eleven patients with sustained PEI and regular enzyme substitution were investigated at hospital, after a washout period without enzyme substitution, and later after reintroduction of substitution. Read More
Med J Aust 2010 Oct;193(8):461-7
Department of Surgery, Flinders Medical Centre, Adelaide, SA, Australia.
Pancreatic exocrine insufficiency (PEI) occurs when the amounts of enzymes secreted into the duodenum in response to a meal are insufficient to maintain normal digestive processes. The main clinical consequence of PEI is fat maldigestion and malabsorption, resulting in steatorrhoea. Pancreatic exocrine function is commonly assessed by conducting a 3-day faecal fat test and by measuring levels of faecal elastase-1 and serum trypsinogen. Read More