Asian Pac J Cancer Prev 2017 10 26;18(10):2781-2785. Epub 2017 Oct 26.
Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malysia. Email:
Vavilovskii Zhurnal Genet Selektsii 2020 Feb;24(1):69-79
Institute of Сhemical Biology аnd Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Noroviruses (the Caliciviridae family) are a common cause of acute gastroenteritis in all age groups. These small non-envelope viruses with a single-stranded (+)RNA genome are characterized by high genetic variability. Continuous changes in the genetic diversity of co-circulating noroviruses and the emergence of new recombinant variants are observed worldwide. Read More
Histol Histopathol 2021 Mar 1:18322. Epub 2021 Mar 1.
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
The pathogenesis of chronic venous disorder (CVeD) remains partially understood. A marked wall remodeling has been shown with potential accelerated tissue senescence. We have investigated the expression of peroxisome proliferator-activated receptor (PPAR) isoforms transcription factor EB (TFEB) as regulatory molecules of cellular homeostasis and makers of peroxisomal and lysosomal biogenesis. Read More
Clin Exp Pharmacol Physiol 2021 Feb 25. Epub 2021 Feb 25.
Institute of Ageing Research, Hangzhou Normal University School of Medicine, Hangzhou, China.
Pulmonary senescence and fibrosis occur with deoxyribonucleic acid (DNA) damage response in the lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that pulmonary alveolar epithelial type 2 cells (AEC2) (alveolar stem cells) undergo not only replicative senescence, but also apoptosis and differentiation in association with increased innate immune natural killer (NK) cells in telomerase knockout (KO) mice. Read More
Front Genet 2021 5;12:597566. Epub 2021 Feb 5.
Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming, China.
Human Werner syndrome (WS) is an autosomal recessive progeria disease. A mouse model of WS manifests the disease through telomere dysfunction-induced aging phenotypes, which might result from cell cycle control and cellular senescence. Both p21 (p21, encoded by the gene) and p16 (p16, encoded by the gene) are cell cycle inhibitors and are involved in regulating two key pathways of cellular senescence. Read More
Int Immunopharmacol 2021 Feb 22;94:107465. Epub 2021 Feb 22.
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Cellular senescence is an irreversible arrest of cell proliferation triggered by different stimuli, including DNA damage, telomere shortening and oncogenic stress. Senescent cells, by releasing the senescence-associated-secretory-phenotype (SASP), contribute to various diseases pathogenesis. Human atherosclerotic plaque contains cells with multiple markers of senescence that associate with disease severity. Read More