Does Moderate Drinking Increase the Risk of Atrial Fibrillation? The Norwegian HUNT (Nord-Trøndelag Health) Study.

J Am Heart Assoc 2017 Oct 20;6(10). Epub 2017 Oct 20.

Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Background: Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population.

Methods And Results: Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8±4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%).

Conclusions: Although alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population.

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.117.007094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721892PMC
October 2017
27 Reads

Publication Analysis

Top Keywords

alcohol intake
16
alcohol consumption
16
risk atrial
8
alcohol
8
association alcohol
8
risk
5
calculated average
4
june 2008
4
2006 june
4
average alcohol
4
october 2006
4
nondrinking calculated
4
2008 1697
4
drinking compared
4
1697 validated
4
47 002 participants
4
compared nondrinking
4
intake 38±48 g/d
4
conducted october
4
cohort study
4

References

(Supplied by CrossRef)

Similar Publications