Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading.

Nanoscale 2017 Oct;9(41):15773-15777

Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, and Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, Texas 77842, USA.

Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.

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Source
http://dx.doi.org/10.1039/c7nr05935cDOI Listing
October 2017

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