Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo.

Authors:

Hassan Fahmi Ismail Zanariah Hashim Wong Tet Soon Nur Syukriah Ab Rahman Ain Nabihah Zainudin Fadzilah Adibah Abdul Majid

J Tradit Complement Med 2017 Oct 16;7(4):452-465. Epub 2017 Jan 16.

Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Malaysia.

Natural antioxidants derived from plants have shown a tremendous inhibitory effect on free radicals in actively metabolizing cells. Overproduction of free radicals increases the risk factor of chronic diseases associated with diabetes, cancer, arthritis and cardiovascular disease. and are ethnomedicinal plants used in the Asian region to treat various illnesses from a common fever to metabolic disease. In this study, we have quantified the total phenolic (TPC) and flavonoid content (TFC) in these plants and its inhibitory effect on 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals as well as the cytotoxicity effect on cell lines proliferation and zebrafish embryogenesis. Results showed that and have the highest phenolic and flavonoid content. Furthermore, both herbs significantly inhibited the formation of DPPH and ABTS free radicals. Meanwhile, exhibited minimum cytotoxicity and embryotoxicity on tested models. Good correlation between IC50 of 3T3-L1 cells and LC50 embyrotoxicity was also found. This study revealed the potent activity of antioxidant against free radical and the toxicology levels of the tested herbal plants.

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http://dx.doi.org/10.1016/j.jtcme.2016.12.006	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634737	PMC

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