Seizure 2017 Nov 19;52:89-116. Epub 2017 Sep 19.
Paediatric Neuropsychology, E Floor, Martin Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, United Kingdom. Electronic address:
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Epilepsia 2011 Aug 8;52(8):1402-8. Epub 2011 Jul 8.
Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany.
Purpose: Because more selective and individual versus extended standard surgery in the treatment of epilepsy appears to result in similar seizure outcomes, the issue of sparing nonlesional and hypothetically still-functioning tissues has become a central topic in epilepsy surgery. Within this framework we hypothesized that surgery in magnetic resonance imaging (MRI)- and histopathologically negative patients with temporal lobe epilepsy (TLE) may serve as a proof of principle about the negative cognitive consequences of resecting nonlesional tissue.
Methods: Verbal and figural memory outcomes after temporal lobe surgery in 15 MRI- and histopathologically negative patients (MRH-) were compared to those obtained in 15 MRI- and histopathologically positive patients (MRH+). Read More
Brain 2015 Jan 12;138(Pt 1):80-93. Epub 2014 Nov 12.
1 Cognitive Neuroscience and Neuropsychiatry Section, Developmental Neurosciences Programme, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK 2 Great Ormond Street Hospital NHS Trust, Great Ormond Street, WC1N 3JH, UK
The temporal lobes play a prominent role in declarative memory function, including episodic memory (memory for events) and semantic memory (memory for facts and concepts). Surgical resection for medication-resistant and well-localized temporal lobe epilepsy has good prognosis for seizure freedom, but is linked to memory difficulties in adults, especially when the removal is on the left side. Children may benefit most from surgery, because brain plasticity may facilitate post-surgical reorganization, and seizure cessation may promote cognitive development. Read More
Pediatr Neurol 1998 Sep;19(3):189-94
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA.
The increased use of surgical intervention for intractable epilepsy during childhood has resulted in a critical need for information concerning possible cognitive and behavioral changes in pediatric patients after surgery. In this pilot study, comprehensive neuropsychologic evaluations were completed on nine children who had a temporal lobectomy for intractable epilepsy before 16 years of age. Performances before and after surgery were compared using cognitive and behavioral measures. Read More
Brain 2005 May 9;128(Pt 5):1188-98. Epub 2005 Mar 9.
Department of Clinical Neurological Sciences, London Health Sciences Centre, London, Ontario, Canada.
Assessment of long-term outcomes is essential in brain surgery for epilepsy, which is an irreversible intervention for a chronic condition. Excellent short-term results of resective epilepsy surgery have been established, but less is known about long-term outcomes. We performed a systematic review and meta-analysis of the evidence on this topic. Read More