Clin Exp Pharmacol Physiol 2018 Mar 20;45(3):261-268. Epub 2017 Dec 20.
Department of Urology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
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Int J Mol Sci 2017 Sep 30;18(10). Epub 2017 Sep 30.
Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka 569-1094, Japan.
High salt intake has been related to the development to chronic kidney disease (CKD) as well as hypertension. In its early stages, symptoms of CKD are usually not apparent, especially those that are induced in a "silent" manner in normotensive individuals, thereby providing a need for some kind of urinary biomarker to detect injury at an early stage. Because traditional renal biomarkers such as serum creatinine are insensitive, it is difficult to detect kidney injury induced by a high-salt diet, especially in normotensive individuals. Read More
Hypertens Res 2016 Jan 17;39(1):19-26. Epub 2015 Sep 17.
Departments of Clinical Pharmacolo.gy, School of Medicine, Jichi Medical University, Tochigi, Japan.
A high salt intake exacerbates hypertension and accelerates renal tubular damage in hypertensive patients. However, data concerning early biomarkers for renal tubular change induced by a high salt intake are limited. The objective of this study was to clarify the time course of new biomarkers for renal tubular damage during high salt intake in spontaneously hypertensive rats (SHR). Read More
J Pharmacol Exp Ther 2012 Jun 7;341(3):656-62. Epub 2012 Mar 7.
Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
Drug-induced nephrotoxicity is a serious problem in patients with hospital-acquired acute kidney injury (AKI). A new renal biomarker is needed because traditional markers are not sensitive for early detection of drug-induced AKI. In a recent study, we demonstrated that vanin-1 is a novel candidate biomarker of nephrotoxicant-induced kidney injury. Read More
J Investig Med 2013 Mar;61(3):564-8
Nephrology Section, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Background: Several biomarkers are becoming available for the early detection of acute kidney injury (AKI), but few have been directly compared.
Objective: To compare urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl glucosaminidase (NAG) against serum creatinine and renal histological score in the initiation, maintenance, and recovery phases of cisplatin (CP)-induced AKI.
Methods: Sprague-Dawley rats (300-350 g) were injected once through their tail veins with CP (CP group) at 5. Read More