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    Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface.

    Am J Physiol Gastrointest Liver Physiol 2018 02 12;314(2):G143-G149. Epub 2017 Oct 12.
    Department of Biological Sciences, University of Calgary , Calgary, Alberta , Canada.
    A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (HS) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. HS donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived HS. When administered together with nonsteroidal anti-inflammatory drugs, HS can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous HS can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury. In this paper we review recent studies examining the roles of HS in mucosal defense, the possibility that HS can damage the gastrointestinal epithelium, and effects of HS on the gut microbiota and on mucus and biofilm interactions in the context of intestinal inflammation.
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