Am J Physiol Gastrointest Liver Physiol 2018 02 12;314(2):G143-G149. Epub 2017 Oct 12.
Department of Biological Sciences, University of Calgary , Calgary, Alberta , Canada.
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Am J Physiol Gastrointest Liver Physiol 2013 Oct 18;305(7):G467-73. Epub 2013 Jul 18.
Dept. of Physiology & Pharmacology, Univ. of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.
Hydrogen sulfide (H2S) is a gaseous meditator that has various physiological and pathophysiological roles in the body. It has been shown to be an important mediator of gastrointestinal (GI) mucosal defense and contributes significantly to repair of damage and resolution of inflammation. Synthesis of H2S increases markedly after mucosal injury, and inhibition of H2S in such circumstances leads to delayed healing and exacerbated inflammation. Read More
Inflamm Bowel Dis 2015 May;21(5):1006-17
Departments of *Biological Sciences, and †Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada; ‡Department of Medicine, McMaster University, Hamilton, ON, Canada; §Centre of Neurosciences and Cell Biology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; and ‖Department of Biology, Lakehead University, Thunder Bay, ON, Canada.
Background: Microbiota dysbiosis and impaired barrier function are among the most prominent features of inflammatory bowel disease. In the gastrointestinal tract, hydrogen sulfide (H(2)S) is an important regulator of mucosal homeostasis. We hypothesized that H(2)S promotes resolution of colonic inflammation through actions on microbiota biofilm and the mucus barrier. Read More
Methods Enzymol 2015 8;555:169-93. Epub 2015 Jan 8.
Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Hydrogen sulfide is an endogenous gaseous mediator that plays important roles in many physiological processes in microbes, plants, and animals. This chapter focuses on the important roles of hydrogen sulfide in protecting tissues against injury, promoting the repair of damage, and downregulating the inflammatory responses. The chapter focuses largely, but not exclusively, on these roles of hydrogen sulfide in the gastrointestinal tract. Read More
Microbiol Spectr 2015 Jun;3(3)
The healthy human intestine is colonized by as many as 1014 bacteria belonging to more than 500 different species forming a microbial ecosystem of unsurpassed diversity, termed the microbiota. The microbiota's various bacterial members engage in a physiological network of cooperation and competition within several layers of complexity. Within the last 10 years, technological progress in the field of next-generation sequencing technologies has tremendously advanced our understanding of the wide variety of physiological and pathological processes that are influenced by the commensal microbiota (1, 2). Read More