BMC Med Genet 2017 10 6;18(1):111. Epub 2017 Oct 6.
Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil.
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J Med Assoc Thai 2014 Jun;97 Suppl 6:S108-14
Background: Down syndrome (DS) is the most common chromosomal abnormality in children. Atrio-ventricular septal defect (AVSD) is the most common congenital heart disease (CHD) reported in DS. The mortality rate of DS with congenital heart disease (CHD) is 5-7 times higher than normal population. Read More
Acta Cardiol 2008 Oct;63(5):585-9
Paediatric Cardiology Division, Paediatrics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Background: Down's syndrome (DS) is the most common chromosomal abnormality due to a trisomy of chromosome 21 commonly associated with congenital heart defects (CHDs). This study aimed to evaluate the frequency and types of CHD patterns in Turkish children with DS.
Method: The data relate to paediatric patients with DS who underwent cardiologic screening between 1994 and 2007 and were reviewed in our Paediatric Cardiology unit. Read More
Int J Cardiol 1990 May;27(2):175-8
Department of Paediatric Cardiology, Hospital of Santa Marta, Lisbon, Portugal.
We have investigated the reasons why female patients with Down's syndrome prevail in our out-patient clinic for Paediatric Cardiology compared to the higher incidence of Down's syndrome among live born male children. We reviewed 277 cases of Down's syndrome, 119 males (42.96%) and 158 females (57. Read More
Heart 2010 Sep 18;96(18):1480-4. Epub 2010 Jul 18.
Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
Background: Congenital heart defects (CHD) are common in patients with Down's syndrome; however, patients living in residential centres have not always been screened for CHD in the past. The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in residential centres, and to determine whether cardiac screening should be recommended.
Methods: Between January 2007 and November 2009 Dutch residential centres nationwide were randomly sampled. Read More