Am J Physiol Gastrointest Liver Physiol 2018 02 28;314(2):G188-G200. Epub 2017 Sep 28.
Department of Neuroscience, Uppsala University , Uppsala , Sweden.
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Am J Physiol Gastrointest Liver Physiol 2016 11 22;311(5):G880-G894. Epub 2016 Sep 22.
Discipline of Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Adelaide, South Australia, Australia.
In vertebrates, visceral pain from internal organs is detected by spinal afferents, whose cell bodies lie in dorsal root ganglia (DRG). Until now, all recordings from spinal afferents have been restricted to recording transmission of action potentials along axons, or from cell bodies lying outside their target organ, which is not where sensory transduction occurs. Our aim was to record directly from a major class of spinal afferent within visceral organs, where transduction of sensory stimuli into action potentials occurs. Read More
J Neurosci 2014 Oct;34(42):14055-68
Department of Neuroscience, Uppsala University, 751 24, Uppsala, Sweden.
Primary afferents are known to use glutamate as their principal fast neurotransmitter. However, it has become increasingly clear that peptides have an influential role in both mediating and modulating sensory transmission. Here we describe the transmission accounting for different acute pain states and itch transmitted via the transient receptor potential cation channel subfamily V member 1 (TRPV1) population by either ablating Trpv1-Cre-expressing neurons or inducing vesicular glutamate transporter 2 (VGLUT2) deficiency in Trpv1-Cre-expressing neurons. Read More
PLoS One 2012 1;7(5):e36355. Epub 2012 May 1.
Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo. To facilitate functional studies of these neurons, we genetically targeted an axonal tracer (farnesylated enhanced green fluorescent protein; GFP) and a LoxP-stopped cell ablation construct (human diphtheria toxin receptor; DTR) to the Calca locus. Read More
Mol Pharmacol 2014 Feb 25;85(2):322-34. Epub 2013 Nov 25.
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is known as a thermosensor and integrator of inflammation-induced hyperalgesia. TRPV1 is expressed in a subpopulation of primary afferent neurons that express several different neurotransmitters. The role of the TRPV1 channel in the development of hyperalgesia is established, but the role of the neurotransmitter glutamate, used partially by the same neuronal population and thus probably mediating the response, is still under investigation. Read More