J Am Acad Dermatol 2018 Mar 28;78(3):637-642. Epub 2017 Sep 28.
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:
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Ann Dermatol 2009 May 31;21(2):209-12. Epub 2009 May 31.
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Hydroa vacciniforme (HV) is a photosensitivity disorder characterized by recurrent necrotic vesiculopapules on sun-exposed areas, which heal spontaneously during adolescence. Recently, an association has been reported between latent Epstein-Barr virus (EBV) infection and atypical HV-like eruption and malignant potential. However, latent EBV infection has also been reported in the setting of typical HV. Read More
Pediatr Dermatol 2010 Sep-Oct;27(5):463-9
Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Hydroa vacciniforme-like cutaneous lymphoma is a rare type of Epstein-Barr virus-associated lymphoma. We analyze clinicopathologic features of seven Chinese child patients with hydroa vacciniforme-like cutaneous lymphoma and determine the pathogenic association of Epstein-Barr virus with this disorder. Clinical, histologic, and immunohistochemical features were reviewed. Read More
Br J Dermatol 2004 Aug;151(2):372-80
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea.
Background: There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV. Several patients have died from a malignant haematological neoplasm. In most cases, a latent Epstein-Barr virus (EBV) infection has been detected in the skin lesions. Read More
J Cutan Pathol 2016 Dec 9;43(12):1102-1111. Epub 2016 Sep 9.
Department of Dermatology, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan.
Background: Hydroa vacciniforme (HV) is associated with Epstein-Barr virus (EBV) infection and a risk of transformation to lymphoma.
Methods: We retrospectively analyzed six HV cases for EBV association and transformation to HV-like T-cell lymphoma. Clinicopathologic features were reviewed and cases were assessed for EBV-encoded RNA (EBER) by in situ hybridization, double staining with immunohistochemistry and EBER and for T-cell clonality. Read More