Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper.

Authors:
Lindsay Lundberg
Lindsay Lundberg
George Mason University
United States
Brian Carey
Brian Carey
Bantry General Hospital
Kylene Kehn-Hall
Kylene Kehn-Hall
United States

Viruses 2017 09 29;9(10). Epub 2017 Sep 29.

National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.

Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus that is vectored by mosquitos and cycled in rodents. It can cause disease in equines and humans characterized by a febrile illness that may progress into encephalitis. Like the capsid protein of other viruses, VEEV capsid is an abundant structural protein that binds to the viral RNA and interacts with the membrane-bound glycoproteins. It also has protease activity, allowing cleavage of itself from the growing structural polypeptide during translation. However, VEEV capsid protein has additional nonstructural roles within the host cell functioning as the primary virulence factor for VEEV. VEEV capsid inhibits host transcription and blocks nuclear import in mammalian cells, at least partially due to its complexing with the host CRM1 and importin α/β1 nuclear transport proteins. VEEV capsid also shuttles between the nucleus and cytoplasm and is susceptible to inhibitors of nuclear trafficking, making it a promising antiviral target. Herein, the role of VEEV capsid in viral replication and pathogenesis will be discussed including a comparison to proteins of other alphaviruses.

Download full-text PDF

Source
http://www.mdpi.com/1999-4915/9/10/279
Publisher Site
http://dx.doi.org/10.3390/v9100279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691631PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
September 2017
42 Reads

Publication Analysis

Top Keywords

veev capsid
20
capsid protein
8
equine encephalitis
8
encephalitis virus
8
venezuelan equine
8
veev
7
capsid
6
polypeptide translation
4
translation veev
4
structural polypeptide
4
inhibitors nuclear
4
additional nonstructural
4
cytoplasm susceptible
4
host cell
4
roles host
4
nonstructural roles
4
protein additional
4
susceptible inhibitors
4
nuclear trafficking
4
making promising
4

Similar Publications