Donor Experiences of Second Marrow or Peripheral Blood Stem Cell Collection Mirror the First, but CD34 Yields Are Less.

Authors:
David F Stroncek
David F Stroncek
National Institutes of Health
United States
Bronwen E Shaw
Bronwen E Shaw
Center for International Blood and Marrow Transplant Research
Milwaukee | United States
Brent R Logan
Brent R Logan
Medical College of Wisconsin
United Kingdom
Deidre M Kiefer
Deidre M Kiefer
CIBMTR (Center for International Blood and Marrow Transplant Research)
Bipin N Savani
Bipin N Savani
Vanderbilt University Medical Center
Nashville | United States
Paolo Anderlini
Paolo Anderlini
The University of Texas MD Anderson Cancer Center
United States
Christopher N Bredeson
Christopher N Bredeson
Medical College of Wisconsin
United States
Peiman Hematti
Peiman Hematti
University of Wisconsin-Madison
United States

Biol Blood Marrow Transplant 2018 01 25;24(1):175-184. Epub 2017 Sep 25.

Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.

Little is known about the experiences of individuals donating peripheral blood stem cells (PBSCs) or marrow for a second time. To study this, unrelated donors making a second donation through the National Marrow Donor Program between 2004 and 2013 were evaluated. Experiences of second-time donors giving marrow (n = 118: first donation was PBSC in 76 and marrow in 42) were compared with those making only 1 marrow donation (n = 5829). Experiences of second-time donors giving PBSCs (n = 602) (first donation was PBSCs in 362; marrow in 240) were compared to first-time PBSC donors (n = 16,095). For donors giving a second PBSC or marrow donation there were no significant differences in maximum skeletal pain, maximum symptoms measured by an established modified toxicity criteria, and recovery time compared with those who donated only once. Notably, the yield of marrow nucleated cells and PBSC CD34 cells with second donations was less. As previously noted with single first-time donations, female (PBSCs and marrow) and obese donors (PBSCs) had higher skeletal pain and/or toxicity with a second donation. PBSC donors who experienced high levels of pain or toxicity with the first donation also experienced high levels of these symptoms with their second donation and slower recovery times. In conclusion, for most donors second donation experiences were similar to first donation experiences, but CD34 yields were less. Knowledge of the donor's first experience and stem cell yields may help centers decide whether second donations are appropriate and institute measures to improve donor experiences.

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Source
http://dx.doi.org/10.1016/j.bbmt.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743544PMC
January 2018
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