New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Authors:
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy

Adv Exp Med Biol 2018 ;1067:373-385

Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.

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http://dx.doi.org/10.1007/5584_2017_106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889357PMC
October 2018
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8 Citations

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