Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission.

Chem Commun (Camb) 2017 Oct;53(80):11091-11094

CAS Key Laboratories of Analytical Chemistry for Living Biosystems and Organic Solids, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

A fast and sensitive method was established for an in-solution selection of cancer cell-targeting peptides at "single-residue resolution" by using the switchable fluorescence of tetraphenylethylene. The selected peptides have potential for biomarker tracing and can be used for targeted delivery of different cargos into living cancer cells.

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http://dx.doi.org/10.1039/c7cc06485cDOI Listing
October 2017
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