Clin Exp Pharmacol Physiol 2018 Apr 11;45(4):349-354. Epub 2017 Dec 11.
Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Download full-text PDF
FASEB J 2012 Feb 28;26(2):947-54. Epub 2011 Oct 28.
SRI International, Menlo Park, California, USA.
Computational methods have led two groups to predict the endogenous presence of a highly conserved, amidated, 14-aa neuropeptide called either spexin or NPQ. NPQ/spexin is part of a larger prohormone that contains 3 sets of RR residues, suggesting that it could yield more than one bioactive peptide; however, no in vivo activity has been demonstrated for any peptide processed from this precursor. Here we demonstrate biological activity for two peptides present within proNPQ/spexin. Read More
Horm Behav 2006 Apr 27;49(4):441-9. Epub 2005 Oct 27.
Department of Psychology, Hunter College and The Graduate Center of the City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Clinical and preclinical studies have found sex-specific differences in the discrimination and perception of inflammatory stimuli. The emerging picture suggests that the biological basis of these differences resides in the regulatory activity of gonadal hormones in the central nervous system. This study describes the effects of ovarian hormones in inflammatory pain processes. Read More
Endocrinology 2009 Aug 9;150(8):3680-9. Epub 2009 Apr 9.
Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA.
A greater incidence of temporomandibular joint (TMJ) pain is reported in females, suggesting that gonadal hormones may play a role in this condition. However, the exact roles of 17beta-estradiol (E2) and progesterone (P4) in TMJ pain are not completely known. Two experiments were performed to determine the separate roles of E2 and P4 in TMJ nociception at various stages of the estrous cycle. Read More
J Pain 2011 Feb 10;12(2):280-7. Epub 2010 Dec 10.
Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Unlabelled: Intracerebroventricular injection of orexin-A (hypocretin-1) has been shown to elicit the analgesic responses. However, the locations of central sites that may mediate these effects have not been clearly elucidated. This study was performed using male Sprague Dawley rats to investigate the antinociceptive effects of intra-periaqueductal gray matter (PAG) administration of orexin-A, 5 minutes prior to formalin (50 μL of 2%) injection. Read More