Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats.

Clin Exp Pharmacol Physiol 2018 Apr 11;45(4):349-354. Epub 2017 Dec 11.

Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Spexin is a central modulator of nociception. The aim of the present study was to investigate the effect of intra-hippocampal CA3 (IHCA3) injection of spexin and spexin-progesterone co-administration on pain sensitivity in ovariectomized rat. Thirty-five adult female rats were divided into five groups. Sham: the animals received injection of 0.5 μL ACSF by IHCA3. Experiments 1 and 2: the animals received injection of 0.5 μL of spexin bilaterally (10 and 30 nmol/rat respectively). Experiments 3 and 4: the animals received injection of 0.5 μL of spexin bilaterally (10 and 30 nmol/rat respectively) + subcutaneous (s.c.) injection of progesterone (5 mg/kg). Ovariectomy was performed in all groups to eliminate the effects of cyclic changes in the female rats. The formalin test (formalin 2.5%) was performed following the administration of spexin and progesterone. Results showed that bilateral injection of spexin in IHCA3 at both concentrations a significant (P < .05) decrease in the pain sensitivity in the two phases of formalin test. Similarly, the bilateral injection of spexin in IHCA3 at both concentrations following the s.c. injection of progesterone significantly (P < .05) decreases pain sensitivity in two phases of the formalin test. This pain attenuation due to the co-administration of spexin and progesterone was more potent than spexin-induced analgesia. According to the present results, spexin has a modulatory effect on pain sensitivity, which becomes more pronounced by progesterone administration.

Download full-text PDF

Source
http://dx.doi.org/10.1111/1440-1681.12862DOI Listing

Still can't find the full text of the article?

Sign up to send a request to the authors directly.
April 2018
6 Reads

Publication Analysis

Top Keywords

received injection
12
animals received
12
injection 05 μl
12
spexin bilaterally
8
05 μl spexin
8
injection spexin
8
experiments animals
8
pain sensitivity
8
female rats
8
bilaterally 30 nmol/rat
8
spexin progesterone
8
injection
6
spexin
6
respectively + subcutaneous injection
4
30 nmol/rat experiments
4
30 nmol/rat respectively + subcutaneous
4
05 μl acsf
4
rats divided
4
adult female
4
divided groups
4

Similar Publications