The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study.

Authors:
Tomoro Hishiki
Tomoro Hishiki
Chiba University Graduate School of Medicine
Japan
Kenichiro Watanabe
Kenichiro Watanabe
Kyoto University Graduate School of Medicine
Kohmei Ida
Kohmei Ida
University of Tokyo
Japan
Ken Hoshino
Ken Hoshino
Keio University School of Medicine
Japan
Tomoko Iehara
Tomoko Iehara
Kyoto Prefectural University of Medicine
Japan
Yuki Aoki
Yuki Aoki
Tokyo Medical and Dental University
Japan
Takuro Kazama
Takuro Kazama
Tohoku University School of Medicine
Japan
Kentaro Kihira
Kentaro Kihira
Mie University Graduate School of Medicine

J Pediatr Surg 2017 Dec 4;52(12):2051-2055. Epub 2017 Sep 4.

Japan Children's Cancer Group (JCCG) liver tumor committee (JPLT).

Background/purpose: The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study.

Methods: A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy.

Results: Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy.

Conclusions: Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected.

Type Of Study: Prospective Cohort Study.

Level Of Evidence: Level II.

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Source
http://dx.doi.org/10.1016/j.jpedsurg.2017.08.031DOI Listing
December 2017
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