Emergence of Echinocandin Resistance Due to a Point Mutation in the Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis.

Authors:
Dr. David Perlin, PhD
Dr. David Perlin, PhD
Hackensack Meridian Health
CSO and Professor
Drug resistance, diangostics
Nutley, NJ | United States

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Public Health Research Institute-New Jersey Medical School-Rutgers Biomedical Health Sciences, Newark, New Jersey, USA.

We have identified the first case of an hot spot 1 point mutation causing echinocandin resistance in a clinical isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.

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Source
http://aac.asm.org/lookup/doi/10.1128/AAC.01277-17
Publisher Site
http://dx.doi.org/10.1128/AAC.01277-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700295PMC
December 2017
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