Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus.

Authors:
John Moran
John Moran
University of Michigan Medical School
United States
Angela X Chen
Angela X Chen
Department of Endocrinology
Scott T Baker
Scott T Baker
University of Minnesota
United States
Michelle Clarke
Michelle Clarke
Mayo Clinic
United States
Richard J MacIsaac
Richard J MacIsaac
University of Melbourne
Australia

Clin Exp Pharmacol Physiol 2018 Jan 25;45(1):94-97. Epub 2017 Oct 25.

Department of Medicine, The University of Melbourne, Melbourne, Vic., Australia.

Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R  = 0.83) with a relative contribution of 53%, 21%, 20% and 6%, respectively. However, there was no interaction between urinary sodium-to-potassium ratio and dipping status.

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http://dx.doi.org/10.1111/1440-1681.12852DOI Listing
January 2018
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