Am J Physiol Gastrointest Liver Physiol 2017 Dec 14;313(6):G589-G598. Epub 2017 Sep 14.
Departments of Medicine and Physiology/Biophysics, University of California, Irvine, California; and Department of Medical Research, Veterans Affairs Medical Center, Long Beach, California
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Am J Physiol Gastrointest Liver Physiol 2014 Jan 21;306(2):G102-10. Epub 2013 Nov 21.
Dept. of Clinical Pharmacology and Therapeutics, Kyoto Univ. Hospital, Sakyo-ku, Kyoto 606-8507, Japan.
Riboflavin, also known as vitamin B2, is transported across the biological membrane into various organs by transport systems. Riboflavin transporter RFVT3 is expressed in the small intestine and has been suggested to localize in the apical membranes of the intestinal epithelial cells. In this study, we investigated the functional involvement of RFVT3 in riboflavin absorption using intestinal epithelial T84 cells and mouse small intestine. Read More
Am J Physiol Gastrointest Liver Physiol 2014 Jan 31;306(2):G123-31. Epub 2013 Oct 31.
Division of Gastaroenterology and Hepatology, Dept. of Medicine, UIC Senior Research Career Scientist, Jesse Brown VAMC, 820 South Damen Ave., Chicago, IL 60612.
SLC26A3 [downregulated in adenoma (DRA)] is a Cl(-)/HCO3(-) exchanger involved in electroneutral NaCl absorption in the mammalian intestine. Altered DRA expression levels are associated with infectious and inflammatory diarrheal diseases. Therefore, it is critical to understand the regulation of DRA expression. Read More
Am J Physiol Gastrointest Liver Physiol 2013 Apr 14;304(8):G741-8. Epub 2013 Feb 14.
Department of Medicine, University of California, Irvine, CA, USA.
Intestinal epithelial cells undergo differentiation as they move from the crypt to the villi, a process that is associated with up- and downregulation in expression of a variety of genes, including those involved in nutrient absorption. Whether the intestinal uptake process of vitamin B(2) [riboflavin (RF)] also undergoes differentiation-dependent regulation and the mechanism through which this occurs are not known. We used human-derived intestinal epithelial Caco-2 cells and native rat intestine as models to address these issues. Read More
Am J Physiol Cell Physiol 2013 Sep 26;305(5):C539-46. Epub 2013 Jun 26.
Department of Medicine and Physiology/Biophysics, University of California, Irvine, California, USA.
Vitamin B2 (riboflavin, RF) is essential for normal human health. Mammals obtain RF from exogenous sources via intestinal absorption and prevent its urinary loss by reabsorption in the kidneys. Both of these absorptive events are carrier-mediated and involve specific RF transporters (RFVTs). Read More