Digestive system in psoriasis: an update.

Authors:
Daniel Pietrzak
Daniel Pietrzak
Medical University of Lublin
Aldona Pietrzak
Aldona Pietrzak
Medical University of Lublin
Poland
Dorota Krasowska
Dorota Krasowska
Medical University of Lublin
Poland
Andrzej Borzęcki
Andrzej Borzęcki
Medical University of Lublin
Maja Baranowska
Maja Baranowska
Institute of Fine Arts
Kristian Reich
Kristian Reich
Georg-August-University
Germany

Arch Dermatol Res 2017 Nov 13;309(9):679-693. Epub 2017 Sep 13.

Dermatologikum Hamburg, Hamburg, Germany.

Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients. Inflammatory bowel diseases (IBD) are also linked with psoriasis. Crohn's disease and ulcerative colitis share a common genetic background, inflammatory pathways and have an evident iatrogenic anti-TNF treatment link, necessitating dermatological or gastroenterological care in patients with IBD or psoriasis, respectively, as well as treatment adjusted to manifestations. The presence of celiac disease-specific antibodies in psoriatic patients and their correlation with the severity of the disease show the association between these disorders. The linking pathogenesis comprises vitamin D deficiency, immune pathway, genetic background and increase in the intestinal permeability, which suggests a potential benefit from gluten-free diet among psoriatic patients. The link between psoriasis and non-alcoholic fatty liver disease implies screening patients for components of metabolic syndrome and lifestyle changes necessity. Some studies indicate increased prevalence of cancer in patients with psoriasis, probably due to negative influence of skin lesion impact on lifestyle rather than the role of psoriasis in carcinogenesis. However, there are no sufficient data to exclude such an oncogenic hit, which is yet to be confirmed. Therefore, all psoriasis-associated comorbidities establish the importance of a multidisciplinary approach in the treatment of these patients.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-017-1775-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648743PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
November 2017
36 Reads

Publication Analysis

Top Keywords

psoriatic patients
12
psoriasis
8
genetic background
8
patients
7
association disorders
4
disorders linking
4
linking pathogenesis
4
pathogenesis comprises
4
disease association
4
severity disease
4
antibodies psoriatic
4
patients correlation
4
correlation severity
4
comprises vitamin
4
vitamin deficiency
4
intestinal permeability
4
permeability suggests
4
suggests potential
4
potential benefit
4
increase intestinal
4

References

(Supplied by CrossRef)
Article in Clin Exp Dermatol
R Abedini et al.
Clin Exp Dermatol 2015
Article in Br J Dermatol
L Abenavoli et al.
Br J Dermatol 2005
Article in Expert Rev Clin Immunol
L Abenavoli et al.
Expert Rev Clin Immunol 2009
Article in Digestion
G Addolorato et al.
Digestion 2003
Article in Oral Surg Oral Med Oral Pathol Oral Radiol
M Alikhani et al.
Oral Surg Oral Med Oral Pathol Oral Radiol 2014
Article in Nat Rev Gastroenterol Hepatol
QM Anstee et al.
Nat Rev Gastroenterol Hepatol 2013
Article in J Dermatol Treat
A Asarch et al.
J Dermatol Treat 2008
Article in J Dermatol Treat
A Asarch et al.
J Dermatol Treat 2008
Article in J Eur Acad Dermatol Venereol
FM Aslanian et al.
J Eur Acad Dermatol Venereol 2005
Article in Am J Med
D Assimakopoulos et al.
Am J Med 2002
Article in Oral Dis
PA Atkin et al.
Oral Dis 2002

Similar Publications