Clin Exp Pharmacol Physiol 2018 Jan 25;45(1):50-57. Epub 2017 Oct 25.
Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China.
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Arterioscler Thromb Vasc Biol 2016 Jan 19;36(1):78-85. Epub 2015 Nov 19.
From the Department of Pharmacology (N.X., S.H., A.H., E.I.C., G.R., U.F., H.L.), Center for Thrombosis and Hemostasis (S.H.), Department of Ophthalmology (A.G.), and Second Medical Department, Cardiology and Angiology (Y.M., T.M., A.D.), Johannes Gutenberg University Medical Center, Mainz, Germany; and German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Mainz, Germany (T.M., A.D., H.L.).
Objective: The present study was conducted to investigate the contribution of perivascular adipose tissue (PVAT) to vascular dysfunction in a mouse model of diet-induced obesity.
Approach And Results: Obesity was induced in male C57BL/6J mice with a high-fat diet for 20 weeks, and vascular function was studied with myograph. In PVAT-free aortas isolated from obese mice, the endothelium-dependent, nitric oxide-mediated vasodilator response to acetylcholine remained normal. Read More
J Mol Cell Cardiol 2013 Oct 9;63:169-74. Epub 2013 Aug 9.
Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China. Electronic address:
To determine whether high free fatty acids (FFA) could affect the anti-contractile properties of perivascular adipose tissue (PVAT) in rat aortas. Wistar rats were divided into normal, obesity and fenofibrate groups and fed a normal, high-fat, and high-fat plus fenofibrate diet, respectively. Thoracic aortas with or without PVAT (PVAT+ and PVAT-) were prepared with either intact endothelium (E+) or with endothelium removed (E-). Read More
Food Funct 2018 Apr;9(4):2409-2415
Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang, China.
Perivascular adipose tissue (PVAT) loses its anti-contractile activity in obesity. Calycosin, the major bioactive isoflavonoid, was shown to protect endothelial function. However, effects of calycosin on PVAT function in obesity remain unclear. Read More
Arterioscler Thromb Vasc Biol 2011 Nov;31(11):2616-23
Department of Cardiovascular Surgery, Xijing Hospital, 4th Military Medical University, Xian, PR China.
Objective: Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest systemic dysfunction unless metabolically challenged. The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as APN paralogs and some CTRP members share APN's metabolic regulatory function. Read More