Cancer Cell 2017 09;32(3):280-281
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:
The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8(+) TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.