Cancer Cell 2017 09;32(3):280-281
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:
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Cancer Cell 2017 09;32(3):377-391.e9
The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:
How tumor-infiltrating T lymphocytes (TILs) adapt to the metabolic constrains within the tumor microenvironment (TME) and to what degree this affects their ability to combat tumor progression remain poorly understood. Using mouse melanoma models, we report that CD8 TILs enhance peroxisome proliferator-activated receptor (PPAR)-α signaling and catabolism of fatty acids (FAs) when simultaneously subjected to hypoglycemia and hypoxia. This metabolic switch partially preserves CD8 TILs' effector functions, although co-inhibitor expression increases during tumor progression regardless of CD8 TILs' antigen specificity. Read More
Int J Mol Sci 2017 Sep 8;18(9). Epub 2017 Sep 8.
Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, 24105 Campus Kiel, Germany.
Tumor-infiltrating lymphocytes (TILs) in breast cancer are a key representative of the tumor immune microenvironment and have been shown to provide prognostic and predictive biomarkers. The extent of lymphocytic infiltration in tumor tissues can be assessed by evaluating hematoxylin and eosin (H&E)-stained tumor sections. We investigated tissue microarrays of 31 invasive breast cancer patients, looking at quantity and topological distribution of CD3+, CD8+, CD20+, Ki67+, FoxP3+ TILs and CD3+/FoxP3+, CD8+/FoxP3+ cell ratios. Read More
Breast Cancer 2017 Jan 2;24(1):3-15. Epub 2016 May 2.
Pathology and Laboratory Medicine, Anatomical Pathology JPN 1401, University of British Columbia, 855 W. 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.
Although unlike melanoma, breast cancer is not generally viewed as a highly immunogenic cancer, recent studies have described a rich tumor immune microenvironment in a subset of breast cancers. These immune infiltrates, comprised cells from the innate and adaptive immune response, can be detected and characterized in biopsy specimens and have prognostic value. Tumor-infiltrating lymphocytes (TILs) represent the majority of mononuclear immune infiltrates in the breast tumor microenvironment and can be easily identified in formalin-fixed paraffin-embedded tissues after standard hematoxylin and eosin staining. Read More
Clin Exp Metastasis 2016 10 23;33(7):727-39. Epub 2016 Jul 23.
Division of Thoracic Surgery, Department of Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
The presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) reflects an active inflammatory tumor microenvironment. High density of TILs as well as presence of TLS is associated with improved survival in various solid cancer types. We aimed to describe the density and distribution of TILs and TLS in pulmonary metastases (PMs) from primary colorectal cancer (CRC) and its correlation with clinicopathological variables. Read More