No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8 TILs.

Authors:
Will Bailis
Will Bailis
Abramson Family Cancer Research Institute
United States
Michael Chiorazzi
Michael Chiorazzi
National Cancer Institute
United States
Richard A Flavell
Richard A Flavell
Yale University School of Medicine
New Haven | United States

Cancer Cell 2017 09;32(3):280-281

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8 TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

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http://dx.doi.org/10.1016/j.ccell.2017.08.013DOI Listing
September 2017
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