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No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8TILs.
Cancer Cell 2017 09;32(3):280-281
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:
The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.
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