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Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation.
Cancer Cell 2017 09;32(3):278-280
CSIRO Health and Biosecurity, PO Box 52, North Ryde, NSW 1670, Australia.
How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.
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