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    When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.

    • Authors:
    • Zhihui Liu
      Development and Utilization Key Laboratory of Northeast Plant Materials
      Carol J Thiele
      National Cancer Institute
      United States
    Cancer Cell 2017 09;32(3):273-275
    Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address:
    LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.
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