Acta Med Port 2017 Jun 30;30(6):472-478. Epub 2017 Jun 30.
IPATIMUP Diagnósticos. Instituto de Patologia e Imunologia Molecular. Universidade do Porto. Porto. Portugal; Departamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
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Braz J Otorhinolaryngol 2014 Sep-Oct;80(5):422-7. Epub 2014 Jul 22.
Hospital São José, Joinville, SC, Brazil.
Introduction: The recently-proposed Bethesda reporting system has offered clinical recommendations for each category of reported thyroid cytology, including repeated fine-needle aspiration (FNA) for non-diagnostic and atypia/follicular lesions of undetermined significance, but there are no sound indications for repeated examination after an initial benign exam.
Objective: To investigate the clinical validity of repeated FNA in the management of patients with thyroid nodules.
Method: The present study evaluated 412 consecutive patients who had repeated aspiration biopsies of thyroid nodules after an initial non-diagnostic, atypia/follicular lesion of undetermined significance, or benign cytology. Read More
Head Neck 2017 02 5;39(2):361-369. Epub 2016 Oct 5.
Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-Gu, Seoul, Korea.
Background: The purpose of this study was to evaluate the role of core-needle biopsy (CNB) by comparing the results of CNB and repeat fine-needle aspiration (FNA) for thyroid nodules that are initially read as atypia/follicular lesion of undetermined significance (AUS/FLUS) on FNA.
Methods: Among 2631 initial AUS/FLUS FNA results, 505 consecutive nodules (295 repeat FNAs and 210 CNBs) were retrospectively analyzed. The primary outcome was inconclusive (ie, nondiagnostic or AUS/FLUS). Read More
Cytopathology 2013 Dec 18;24(6):385-90. Epub 2012 Oct 18.
Departments of PathologyEndocrinology and Metabolism, Yildirim Beyazit University, Ankara Ataturk Research and Education Hospital, Ankara, Turkey.
Objective: To report our experience of atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS) rate and outcome.
Methods: Among 7658 patients with 19 569 nodules, 524 (2.7%) nodules were diagnosed as AUS/FLUS on fine needle aspiration (FNA). Read More
Eur Radiol 2015 Sep 5;25(9):2601-7. Epub 2015 Mar 5.
Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 120-752.
Purpose: To evaluate the malignancy risk and characteristics of thyroid nodules with two "Atypia of Undetermined Significance" or "Follicular Lesion of Undetermined Significance" (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result.
Methods: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. Read More