Asian J Psychiatr 2017 Dec 1;30:120-121. Epub 2017 Sep 1.
Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India. Electronic address:
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Encephale 2016 Jun 26;42(3):277-80. Epub 2016 Feb 26.
Pôle Santé Publique, Pharmacovigilance, CHU Grenoble-Alpes, 38000 Grenoble, France.
Background: Neuroleptic malignant syndrome (NMS) is an uncommon but potentially fatal adverse effect of neuroleptic drugs. It is commonly characterized by muscular rigidity, fever, altered mental status, and autonomic dysfunction. Emerging of NMS is possible with all neuroleptics, classic and atypical. Read More
Int J Psychiatry Med 2015 ;49(1):35-43
Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home, Taiwan
Objectives: Neuroleptic malignant syndrome (NMS) requires emergency treatment and can be fatal. Combined aripiprazole and clozapine therapy is rarely used in clinical settings, and NMS related this combination still lacks evaluation. Herein, we present two cases of atypical NMS treated with aripiprazole and clozapine. Read More
Encephale 2008 Dec 2;34(6):618-24. Epub 2008 Apr 2.
Background: Neuroleptic malignant syndrome (NMS) is an uncommon, but potentially life threatening complication of neuroleptic drugs. In 1960, Delay et al. [Ann Med Psychol 118 (1960) 145-152] described the "syndrome akinétique hypertonique"(hypertonic akinetic syndrome) and its cardinal symptoms: hyperthermia, extrapyramidal symptoms, altered mental status and autonomic dysfunctions. Read More
Fortschr Neurol Psychiatr 1993 Jun;61(6):217-22
Psychiatrische Klinik, Universität Würzburg.
Clozapine is an atypical neuroleptic drug characterised by a striking lack of extrapyramidal side effects. Although these features would seem to make clozapin an unlikely agent for the induction of neuroleptic malignant syndrome (NMS), several putative clozapin-related cases of NMS have recently been reported. A reevaluation of these articles raised some doubts on the causal relationship between clozapin therapy and NMS in most cases. Read More