Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    [Effect of the cellular and humoral immune response in infertile couples and its relationship with infections.]

    • Authors:
    • Adriana Brufman
      Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario (UNR).Departamento de Bioquímica Clínica UNR
      Rosario | Argentina
      Laura Colombo
      Department of Molecular Biochemistry and Pharmacology
      Boston | United States
      Esteban Streiger
      Servicio Urología. Hospital Escuela Eva Perón. Argentina
      Granadero Baigorria | Argentina
    Arch Esp Urol 2017 Sep;70(7):662-668
    Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario (UNR).Departamento de Bioquímica Clínica UNR.
    Objective: The purpose of this study was to determine the prevalence of different microorganisms isolated from the urogenital tract of infertile men and assess whether there are differences in semen parameters according to the presence or absence of genital infections.

    Methods: 280 semen samples from infertile men were studied retrospectively. Semen parameters were analyzed according to the World Health Organization criteria (WHO 2010). Microbiological analysis was performed using the modified method of Stamey and Meares proposed by Santoianni et al.

    Results: Microbiological studies showed absence of microorganisms or presence of usual colonizing flora in 67.86% of the samples (GROUP 1) and presence of at least one pathogen or potential pathogen in 32.14% (GROUP 2). No significant differences in ejaculate volume (p=0.353), pH value (p=0.801), motility (p>0.30), citric acid concentration (p=0.383) and viscosity (p=0.948) were observed between the two groups. The relative sperm count was significantly lower in infected patients than in those without pathogens (p=0.05). Teratozoospermia index (TZI) was evaluated. Samples of infected patients showed TZI values higher than patients without microorganisms or normal genital tract flora (p<0.0001).

    Conclusions: A third of the studied population had genital infections. Based on our results, sperm culture may be considered in the early stages of the study of the infertile patient. Early diagnosis of an infectious disease could be useful for a suitable treatment for couples with reproductive failure.

    Similar Publications

    Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men.
    BMC Infect Dis 2007 Nov 8;7:129. Epub 2007 Nov 8.
    Department of Microbiology and research Laboratory Microorganismes et Pathologie Humaine, Habib BOURGUIBA Hospital-Sfax-TUNISIA.
    Background: Genital ureaplasmas (Ureaplasma urealyticum and Ureaplasma parvum) and mycoplasmas (Mycoplasma genitalium and Mycoplasma hominis) are potentially pathogenic species playing an etiologic role in both genital infections and male infertility. Reports are, however, controversial regarding the effects of these microorganisms infections in the sperm seminological variables. This study aimed at determining the frequency of genital ureplasmas and mycoplasmas in semen specimens collected from infertile men, and at comparing the seminological variables of semen from infected and non-infected men with these microorganisms. Read More
    IgA antibodies to Chlamydia trachomatis and seminal parameters in asymptomatic infertile males.
    Arch Androl 2001 May-Jun;46(3):189-95
    Universidad de Oriente, Escuela de Medicina, Departamento de Ciencias Fisiológicas, Ciudad Bolívar, Venezuela.
    Prevalence of IgA antibodies to Chlamydia trachomatis in semen samples from infertile men was estimated and its clinical meaning is discussed. The ejaculate of 102 infertile men without any symptom of genital infection was studied, and seminal alterations were classified according to WHO criteria. Antichlamydial IgA antibodies were detected using a solid-phase, enzyme-linked immunoassay (ImmunoComb II Chlamydia trachomatis monovalent IgA) and related to sperm count, motility and membrane integrity, seminal leucocyte count, and past history of sexually transmitted disease (STD). Read More
    Chlamydia trachomatis and male infertility in Tunisia.
    Eur J Contracept Reprod Health Care 2001 Jun;6(2):102-7
    Laboratory of Bacteriology-Virology, University School of Medicine Sfax, Tunisia.
    Objective: Chlamydia trachomatis is a common sexually transmitted micro-organism. The impact of chlamydial infection on semen parameters and male fertility is controversial. Our purpose was to determine the prevalence of C. Read More
    Concordance of Ureaplasma urealyticum and Mycoplasma hominis in infertile couples: impact on semen parameters.
    Urology 2013 Jun 18;81(6):1219-24. Epub 2013 Apr 18.
    Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, Jung-gu, Seoul, Korea.
    Objective: To assess the relationship between mycoplasma infection and human infertility, we determined the concordance of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) detection in infertile and fertile couples, and assessed semen parameters in both groups.

    Methods: Fifty infertile couples without a female factor attending a fertility clinic and 48 fertile couples were randomly screened for UU and MH. The concordance between partners was compared between the fertile and infertile groups. Read More