Perillyl alcohol protects human renal tubular epithelial cells from hypoxia/reoxygenation injury via inhibition of ROS, endoplasmic reticulum stress and activation of PI3K/Akt/eNOS pathway.

Biomed Pharmacother 2017 Nov 7;95:662-669. Epub 2017 Sep 7.

Department of Pediatrics, The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Ischemia Reperfusion Injury Institute, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Ischemia/reperfusion (I/R) injury plays an essential role in renal transplantation, and represents a crucial risk factor for allograft dysfunction and acute renal failure. Modulation of oxidative stress is an effective therapeutic strategy for I/R injury. Perillyl alcohol (POH), a dietary monoterpene with antioxidant activity is found in a variety of plants. The study was carried out to investigate whether treatment of POH could reduce hypoxia/reoxygenation (H/R)-induced injury. H/R induced significant injury in HK-2 cells. H/R caused an increase in ROS level, apoptosis and ER stress. Meanwhile H/R also inhibited the cell viability and PI3K/Akt/eNOS signaling pathway. Pretreatment with POH prior to H/R improved cell viability, reduce ROS level, ER stress and apoptosis. Moreover, POH could also activate the PI3K/Akt/eNOS pathway. Therefore, POH may possess protective effects in H/R-induced cellular damage.

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http://dx.doi.org/10.1016/j.biopha.2017.08.129DOI Listing
November 2017

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