The TREX1 Dinosaur Bites the Brain through the LINE.

Cell Stem Cell 2017 09;21(3):287-288

Pfizer - University of Granada - Andalusian Government Center for Genomics and Oncological Research (GENYO), PTS, 18016, Granada, Spain; Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institute, Solna, 171 77, Sweden. Electronic address:

In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.

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http://dx.doi.org/10.1016/j.stem.2017.08.010DOI Listing
September 2017
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