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    Effect of Cardiac Surgery-Associated Acute Kidney Injury on Long-Term Outcomes of Chinese Patients: A Historical Cohort Study.

    • Authors:
    • Buyun Wu
      Nanjing University School of Medicine
      Lulu Ma
      Rice University
      Houston | United States
      Yongfeng Shao
      The First Affiliated Hospital of Nanjing Medical University
      Si Liu
      School of Public Health
      Xiangbao Yu
      The First Affiliated Hospital of Nanjing Medical University
      Yamei Zhu
      College of Chemistry and Chemical Engineering
      Xianrong Xu
      General Hospital of Air Force
      Changying Xing
      The First Affiliated Hospital of Nanjing Medical University
      Nanjing Shi | China
      Huijuan Mao
      The First Affiliated Hospital of Nanjing Medical University
      Nanjing Shi | China
    Blood Purif 2017 6;44(3):227-233. Epub 2017 Sep 6.
    Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
    Background/aims: To evaluate the long-term outcomes of Chinese patients with cardiac surgery-associated acute kidney injury (CSA-AKI).

    Methods: Patients who underwent cardiac surgery with a median 3-year follow-up were enrolled. The long-term survival rate and the incidence of chronic kidney disease (CKD) were recorded, and related risk factors were analyzed.

    Results: Of all 1,363 patients, 457 (33.5%) developed CSA-AKI. The AKI patients had a lower 3-year survival rate (88.8 vs. 97.2%, respectively, p < 0.001) and a higher incidence of CKD stages 3-5 (9.9 vs. 2.3%, respectively, p < 0.001) than the non-AKI patients. Cox regression analysis showed that AKI, atrial fibrillation, chronic cardiac insufficiency, longer surgical duration, respiratory failure after surgery, and longer mechanical ventilation time were associated with long-term mortality, while AKI, older age, and lower baseline kidney function were associated with incident CKD stages 3-5.

    Conclusion: CSA-AKI increased the risk of 3-year mortality and incident CKD stages 3-5.
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