High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes.

Diab Vasc Dis Res 2017 11 2;14(6):468-476. Epub 2017 Sep 2.

1 Department of Cardiology, Hospital of Southwest Denmark, Esbjerg, Denmark.

Purpose: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.

Methods: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.

Results: Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm; 0-50.5 mm vs 0; 0-34.3 mm, p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume ( τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume ( p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.

Conclusion: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

Download full-text PDF

Source
http://dx.doi.org/10.1177/1479164117728014DOI Listing
November 2017
5 Reads

Publication Analysis

Top Keywords

type diabetes
8
patients newly
8
newly diagnosed
8
study compare
4
compare presence
4
diabetes age-
4
asymptomatic patients
4
purposes study
4
diagnosed type
4
presence extent
4
coronary plaques
4
composition coronary
4
extent composition
4
purpose purposes
4
plaques asymptomatic
4
age- sex-matched
4
coronary atherosclerosis
4
atherosclerosis patients
4
controlsmethods patients
4
burden coronary
4

References

(Supplied by CrossRef)

Similar Publications