Acta Med Port 2017 May 31;30(5):421-425. Epub 2017 May 31.
Oxford Centre for Diabetes, Endocrinology and Metabolism. Churchill Hospital. Oxford. United Kingdom.
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Tex Heart Inst J 2014 Oct 1;41(5):533-6. Epub 2014 Oct 1.
Carcinoid tumors are rare neuroendocrine malignancies that typically originate from the gastrointestinal tract. Patients who are diagnosed with carcinoid heart disease generally have poor prognoses because of advanced metastases during staging and few therapeutic options. We present the case of a 61-year-old woman with right-sided heart failure, secondary to carcinoid heart disease caused by a primary ovarian carcinoid tumor. Read More
Acta Gastroenterol Belg 2009 Jan-Mar;72(1):34-8
Department of Gastroenterology, University Hospital Gent, Gent, Belgium.
Carcinoid heart disease (CHD) develops in serotonin-producing neuroendocrine tumours (NET) due to fibrotic endocardial plaques with associated valve dysfunction leading most often to right-sided heart failure. The classical carcinoid syndrome usually occurs when serotonin-producing NET metastasize to the liver. Up to 50% of those patients will exhibit carcinoid heart disease. Read More
Heart Lung Circ 2015 Jul 24;24(7):e97-e100. Epub 2015 Feb 24.
Icahn School of Medicine, Mount Sinai Medical Center, NY, USA.
Carcinoid heart disease, caused by primary ovarian carcinoid tumour, is a rare form of valvular heart disease. This form of heart disease usually presents with symptoms of right-sided valvular dysfunction, ultimately leading to right-sided heart failure. This entity is unique as it develops in the absence of liver metastasis. Read More
Acta Cardiol 2010 Dec;65(6):709-12
Department of Cardiology, Heilig-Hart Hospital, Roeselare, Belgium.
Carcinoid heart disease (CHD) is a rare form of valvular heart disease characterized by right-sided heart valve dysfunction. Carcinoid heart disease occurs most frequently when carcinoid tumour cells metastasize from a primary site in the gut to the liver, so that vasoactive substances produced by the tumour are able to reach the systemic circulation. By contrast, in ovarian carcinoid tumours carcinoid heart disease develops in the absence of liver metastasis, because vasoactive substances can be released directly into the systemic circulation, bypassing the first-pass metabolism of the liver. Read More