Annu Rev Genomics Hum Genet 2017 08;18:277-296
Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom.
The history of the Americas involved the encounter of millions of Native Americans, Europeans, and Africans. A variable admixture of these three continental groups has taken place throughout the continent, influenced by demography and a range of social factors. This variable admixture has had a major influence on the genetic makeup of populations across the continent. Here, we summarize the demographic history of the region, highlight some social factors that affected historical admixture, and review major patterns of ancestry across the Western Hemisphere based on genetic data.