MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice.

Neuropediatrics 2018 02 31;49(1):3-11. Epub 2017 Aug 31.

Department of Pediatric Neurology, Vestische Kinder- und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany.

Myelin oligodendrocyte glycoprotein (MOG) antibodies (abs) are present in one third of all children with an acute demyelinating syndrome (ADS). MOG-abs can be found in acute disseminated encephalomyelitis (ADEM), transverse myelitis, isolated optic neuritis (ON), or recurrent demyelinating diseases, such as multiphasic neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 (AQP4) abs or multiphasic ADEM (MDEM), but rarely in children who subsequently develop multiple sclerosis (MS). The presence of MOG-abs is age dependent with the highest seropositivity rates found in young children and an episode of ADEM, whereas older children with MOG-abs present with ON, myelitis, or brainstem symptoms. MOG-abs, initially thought to be associated with a benign disease course, are found in a substantial proportion of children with relapsing episodes associated with high and persisting MOG-ab titers. This review describes, in particular, the increasing spectrum of phenotypes associated with MOG-abs with a focus on clinical characteristics, radiological features, and therapeutic aspects.

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0037-1604404DOI Listing
February 2018

Publication Analysis

Top Keywords

spectrum disorders
8
mog-abs
5
children
5
adem mdem
4
multiphasic adem
4
abs multiphasic
4
aquaporin-4 aqp4
4
aqp4 abs
4
mdem rarely
4
children subsequently
4
symptoms mog-abs
4
rarely children
4
titers review
4
mog-ab titers
4
mog-abs initially
4
diseases multiphasic
4
describes increasing
4
demyelinating diseases
4
increasing spectrum
4
recurrent demyelinating
4

Similar Publications