Am J Clin Pathol 2015 May;143(5):635-44
From the Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objectives: We investigated mutation profiles of CALR, JAK2, and MPL in 199 Korean patients with myeloproliferative neoplasms (MPNs).
Methods: In total, 199 patients with MPN (54 primary myelofibrosis [PMF], 79 essential thrombocythemia [ET], 58 polycythemia vera [PV], and eight MPN-unclassifiable [MPN-U]) and 4 patients with acute panmyelosis with myelofibrosis (APMF) were retrospectively subjected to Sanger sequencing for CALR, JAK2, and MPL.
Results: The overall frequency of CALR mutations was 12. Read More