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Curr Pharm Biotechnol 2017 Nov;18(8):662-668

Clinical Biochemistry Unit, Faculty of Pharmacy and Biotechnology, the German University in Cairo, Cairo, Egypt.

Background: Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Read More

J Tehran Heart Cent 2017 Apr;12(2):72-81

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

The C1019T polymorphism of the connexin-37 (GJA4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. We examined the association between the C1019T polymorphism of the GJA4 gene and the occurrence of myocardial infarction (MI) in patients with premature coronary artery disease (CAD). Our study recruited 1000 patients with the final diagnosis of premature CAD and classified them into 2 groups: with a history of MI (n = 461) and without it (n = 539). Read More

Eur J Obstet Gynecol Reprod Biol 2016 Jan 22;196:17-20. Epub 2015 Nov 22.

Department of Biochemistry, Osmania University, Hyderabad, India. Electronic address:

Objective: Polycystic ovarian syndrome (PCOS) is a complex and multifactorial disorder believed to be the consequence of a complex interaction between genetic, immunological, and environmental factors. The main aim of this study was to investigate the association of Connexin37 (Cx37)/Gap junction alpha 4 (GJA4) gene C1019T single nucleotide polymorphism (SNP) with the susceptibility to polycystic ovarian syndrome (PCOS) in South Indian women.

Study Design: This study comprises 98 PCOS patients and 100 healthy women without PCOS of South Indian origin. Read More

Minerva Cardioangiol 2016 Apr 11;64(2):114-20. Epub 2014 Dec 11.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Shandong University, Qilu Hospital, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, Shandong, China -

Background: The aim of this paper was to investigate the association between the connexin 37 (CX37) 1019C/T polymorphism and susceptibility to dilated cardiomyopathy (DCM).

Methods: Han Chinese diagnosed with DCM between 2005 and 2013 were studied, and they were compared with a control group of 816 persons without DCM from a patient cohort from the Provincial Hospital Affiliated to Anhui Medical University, China. A total of 873 patients with DCM were included. Read More

Exp Gerontol 2014 Oct 14;58:203-7. Epub 2014 Jun 14.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China. Electronic address:

Background: Several studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory.

Methods And Results: Pubmed, Embase, and Cochrane library databases were systemically searched. Read More