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    Increased urinary pyridinoline cross-link compounds of collagen in patients with systemic sclerosis and Raynaud's phenomenon.
    Rheumatology (Oxford) 2001 Feb;40(2):140-6
    Research Institute of Rheumatic Diseases, Piest'any, Slovak Republic.
    Objective: To study concentration changes in collagen degradation markers in patients with diffuse and limited cutaneous systemic sclerosis and patients with scleroderma-related diseases.

    Methods: Pyridinoline cross-link compounds were analysed in urine samples using high-performance liquid chromatography. Samples were analysed for pyridinoline (Pyr), deoxypyridinoline (Dpyr) and soft-tissue pyridinoline (stPyr) in patients with diffuse cutaneous systemic sclerosis (dcSSc, n=23) and limited cutaneous systemic sclerosis (lcSSc, n=48) and in patients with scleroderma-related diseases such as primary Raynaud's phenomenon (pRP, n=16) and secondary Raynaud's phenomenon (sRP, n=14). Read More
    Systemic sclerosis sine scleroderma and calcinosis cutis: report of a rare case.
    Clin Rheumatol 2010 Feb 17;29(2):215-9. Epub 2009 Oct 17.
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, 171001, Himachal Pradesh, India.
    Systemic sclerosis sine scleroderma is a rare form of limited cutaneous scleroderma. These patients manifest without cutaneous involvement, but do not differ in its clinical or laboratory features and prognosis from classical systemic sclerosis. In the absence of cutaneous signs/symptoms, its diagnosis is delayed leading to morbidity. Read More
    [Botulinum toxin type A contribution in the treatment of Raynaud's phenomenon due to systemic sclerosis].
    Ann Chir Plast Esthet 2013 Dec 26;58(6):658-62. Epub 2011 Dec 26.
    Service de chirurgie de la main, CHU Conception, 145, boulevard Baille, 13005 Marseille, France.
    Aims: Raynaud's phenomenon is a vasospastic disorder of the extremities that can lead, in the hands, to pain, disability, ischemic ulcers and digital chronic ischemia. Medical and surgical current treatments are not fully effective while causing side effects. Recent studies have emphasized the value of botulinum toxin type A (BTX A) in the management of primary Raynaud's phenomenon. Read More
    Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.
    Semin Arthritis Rheum 2016 Oct 18;46(2):200-8. Epub 2016 May 18.
    Department of Internal Medicine, Hospital Valld'Hebron, Barcelona, Spain.
    Objective: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc.

    Methods: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Read More