J Invest Dermatol 2017 Dec 12;137(12):2473-2483. Epub 2017 Aug 12.
Rheumatology Division, Feinberg School of Medicine, Chicago, Illinois, USA.
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Arthritis Rheum 2012 Aug;64(8):2734-45
Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Objective: Fibrosis in human diseases and animal models is associated with aberrant Wnt/β-catenin pathway activation. The aim of this study was to characterize the regulation, activity, mechanism of action, and significance of Wnt/β-catenin signaling in the context of systemic sclerosis (SSc).
Methods: The expression of Wnt signaling pathway components in SSc skin biopsy specimens was analyzed. Read More
Ann Rheum Dis 2012 May 10;71(5):761-7. Epub 2012 Feb 10.
Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Objectives: Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis. Read More
Arthritis Rheum 2011 Jun;63(6):1707-17
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Objective: Because aberrant Wnt signaling has been linked with systemic sclerosis (SSc) and pulmonary fibrosis, we sought to investigate the effect of Wnt-10b on skin homeostasis and differentiation in transgenic mice and in explanted mesenchymal cells.
Methods: The expression of Wnt-10b in patients with SSc and in a mouse model of fibrosis was investigated. The skin phenotype and biochemical characteristics of Wnt-10b-transgenic mice were evaluated. Read More
Arthritis Rheum 2013 May;65(5):1335-46
Boston University School of Medicine, Boston, Massachusetts 02118-2526, USA.
Objective: To explore the expression of thymic stromal lymphopoietin (TSLP) in patients with diffuse cutaneous systemic sclerosis (dcSSc) and compare its effects in vivo and in vitro with those of interleukin-13 (IL-13) and transforming growth factor β (TGFβ).
Methods: Skin biopsy specimens from patients with dcSSc (n = 14) and healthy controls (n = 13) were analyzed by immunohistochemistry and immunofluorescence for TSLP, TSLP receptor, CD4, CD8, CD31, and CD163 markers. Wild-type, IL-4Rα1-, and TSLP-deficient mice were treated with TGFβ, IL-13, poly(I-C), or TSLP by osmotic pump. Read More