Brain Sci 2017 Aug 12;7(8). Epub 2017 Aug 12.
The Sastry Foundation Advanced Imaging Laboratory, Wayne State School of Medicine, 4201 St Antoine, Detroit 48201, MI, USA.
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Neuroimage Clin 2015 27;8:440-7. Epub 2014 Dec 27.
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA ; Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Background: Cortical, thalamic and hippocampal gray matter atrophy in relapsing-remitting MS (RRMS) is associated cognitive deficits. However, the role of interconnecting white matter pathways including the fornix, cingulum, and uncinate fasciculus (UF) is less well studied.
Objective: To assess MS damage to a hippocampal-thalamic-prefrontal network and the relative contributions of its components to specific cognitive domains. Read More
Mult Scler Relat Disord 2016 Jan 21;5:29-33. Epub 2015 Oct 21.
Department of Neurology, University of California San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Background: Fatigue is a common and disabling symptom of multiple sclerosis (MS) patients. Structural changes in several brain areas have been reported to correlate with fatigue in MS patients but none consistently.
Objective: To study the association between global and regional measures of brain atrophy and fatigue in patients with early relapsing MS. Read More
Radiology 2011 Dec 26;261(3):891-8. Epub 2011 Oct 26.
Department of Neurosciences, Multiple Sclerosis Centre of Veneto Region-First Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padua, Italy.
Purpose: To evaluate whether diffusion-tensor imaging can be combined with double inversion recovery to improve the detection of structural changes occurring in the cortex of patients with multiple sclerosis (MS).
Materials And Methods: Once local ethics committee approval and informed consent were obtained, 168 patients with relapsing-remitting MS and 45 sex- and age-matched control subjects were included in a 3-year longitudinal study. Expanded Disability Status Scale (EDSS) and magnetic resonance (MR) imaging examinations were performed at study entry and after 3 years. Read More
AJNR Am J Neuroradiol 2009 Aug 15;30(7):1380-6. Epub 2009 Apr 15.
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Background And Purpose: Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.
Materials And Methods: Twenty-four patients with relapsing-remitting (RR, n = 13, age = 41. Read More