Neuroscience 2017 Jul 29. Epub 2017 Jul 29.
Dipartimento di Neurologia e Psichiatria, Sapienza Università di Roma, 00185 Roma, Italy; IRCCS Neuromed, 86077 Pozzilli, IS, Italy.
Download full-text PDF
ACS Chem Neurosci 2016 Apr 25;7(4):470-83. Epub 2016 Mar 25.
Neuro-Immunology, Neurology Division, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1011 Lausanne, Switzerland.
Neuroinflammation is implicated in the pathophysiology of a growing number of human disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic lateral sclerosis. As a result, interest in the development of novel methods to investigate neuroinflammatory processes, for the purpose of diagnosis, development of new therapies, and treatment monitoring, has surged over the past 15 years. Neuroimaging offers a wide array of non- or minimally invasive techniques to characterize neuroinflammatory processes. Read More
Biophys Rev 2010 May 2;2(2):83-90. Epub 2010 Apr 2.
Centre de Résonance Magnétique Biologique et Médicale - UMR CNRS 6612 - Faculté de Médecine, Université de la Méditerranée, Marseille, 13005, France.
Magnetic resonance imaging (MRI) has considerably improved the diagnosis and monitoring of multiple sclerosis (MS). Conventional MRI such as T-weighted and gadolinium-enhanced T-weighted sequences detect focal lesions of the white matter, damage of the blood-brain barrier, and tissue loss and inflammatory activity within lesions. However, these conventional MRI metrics lack the specificity required for characterizing the underlying pathophysiology, especially diffuse damage occurring throughout the whole central nervous system. Read More
Lijec Vjesn 2006 Sep-Oct;128(9-10):295-308
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute and Baird MS Research Center, Department of Neurology, School of Medicine and Biomedical Sciences University Buffalo, State University of New York, Buffalo, NY, USA.
Multiple sclerosis is an autoimmune disease characterized by demyelination and axonal loss. Conventional magnetic resonance imaging allows the demonstration of spatial and temporal dissemination of multiple sclerosis lesions earlier than is possible from clinical assessments. A variety of conventional magnetic resonance imaging protocols, in conjunction with clinical assessment, are now routinely used to increase the accuracy of diagnosis and long-term prognosis of multiple sclerosis. Read More
Chin Med J (Engl) 2012 Jul;125(13):2361-4
Department of Radiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Objective: To summarize the main findings seen on conventional and advanced magnetic resonance imaging (MRI) used to assess gray matter (GM) involvement in patients with multiple sclerosis (MS).
Data Sources: The data used in this review were obtained mainly from studies reported in the PubMed database using the terms of multiple sclerosis, gray matter, magnetic resonance imaging.
Study Selection: Relevant literatures on studies of GM involvement in MS patients were identified, retrieved and reviewed. Read More