Int J Mol Sci 2017 Jul 25;18(8). Epub 2017 Jul 25.
Imaging Division, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherland.
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BMC Biotechnol 2017 05 18;17(1):45. Epub 2017 May 18.
Department of Physics, Ryerson University, 350 Victoria Street Toronto, Ontario, M5B 2K3, Canada.
Background: Ultrasound and microbubbles (USMB) have been shown to enhance the intracellular uptake of molecules, generally thought to occur as a result of sonoporation. The underlying mechanism associated with USMB-enhanced intracellular uptake such as membrane disruption and endocytosis may also be associated with USMB-induced release of cellular materials to the extracellular milieu. This study investigates USMB effects on the molecular release from cells through membrane-disruption and exocytosis. Read More
PLoS One 2016 8;11(6):e0156754. Epub 2016 Jun 8.
Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. Read More
J Control Release 2016 09 29;238:157-165. Epub 2016 Jul 29.
Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
The possibility to enhance drug delivery by using ultrasound in combination with microbubbles (USMB) is extensively studied. So far, these studies have focused on the delivery and efficacy of a single drug, e.g. Read More
Ultrasonics 2015 Mar 19;57:36-43. Epub 2014 Oct 19.
Department of Physics, Ryerson University, Toronto, Canada. Electronic address:
Background: Gold nanorod (AuNR) laser therapy (LT) is a non-invasive method of increasing the temperature of a target tissue using near infrared light. In this study, the effects of ultrasound and microbubbles (USMB) with AuNR and LT were investigated on cell viability.
Methods: MDA-MB-231 cells in suspension were treated with three different treatment combinations of AuNR, LT and USMB (Pneg=0. Read More