Pathol Res Pract 2017 Nov 6;213(11):1440-1444. Epub 2017 Jul 6.
Rush University Medical Center, Department of Pathology, 1653 West Congress Parkway, 570 Jelke, Chicago, IL 60612, USA.
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Pediatr Neurol 2014 Oct 24;51(4):576-9. Epub 2014 Jun 24.
Department of Diagnostic Radiology, University of Missouri School of Medicine, Columbia, Missouri.
Background: The triad of leukoencephalopathy with cerebral calcifications and cysts is a rare syndrome consisting of these three radiographic findings first described by Labrune et al. in 1996. The inheritance pattern and genetic mutation responsible for this syndrome (if any) have not been determined. Read More
Ann Indian Acad Neurol 2011 Oct;14(4):310-2
Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Triad of leukoencephalopathy, cerebral calcifications and cysts (LCC) is a recently reported rare disease named 'Labrune syndrome' after the first case was reported in 1996 by Labrune et al. Herein, we report a case of a 36-year-old man with mild right-sided weakness and seizures for 5 years. CT of brain revealed extensive calcification involving bilateral basal ganglia, right thalamus and bilateral deep cerebellar nuclei. Read More
Ann Indian Acad Neurol 2010 Oct;13(4):299-301
Department of Neurological Sciences, Baby Memorial Hospital, Calicut, Kerala, India.
Leukoencephalopathy, intracranial calcifications, and cysts (LCC) is a very rare cerebral disorder, first described in 3 children in 1996. It has subsequently been reported in adults and children from Europe and America, but has not so far been reported from Asia. We report an adult patient with pathologically proven LCC from a tertiary care hospital in South India. Read More
J Neuropathol Exp Neurol 2009 Apr;68(4):432-9
Department of Pathology, University of Colorado, Denver, Anschutz Medical Campus, Aurora, Colorado, USA.
Leukoencephalopathy with cerebral calcifications and cysts (LCC) was first reported in children who developed cognitive decline and variable extrapyramidal, cerebellar, and pyramidal signs, with or without seizures. Leukoencephalopathy with cerebral calcifications and cysts is characterized by progressive formation of brain cysts that can generate a mass effect simulating a neoplasm. Retinal changes that overlap with Coats disease, a microangiopathy with retinal telangiectasias and exudates, may also occur. Read More