Semin Diagn Pathol 2017 Sep 28;34(5):427-437. Epub 2017 May 28.
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
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Akush Ginekol (Sofiia) 2006 ;45(2):33-9
Fibroblastic and myofibroblastic lesions are challenging because they occur infrequently and there is significant clinical, radiologic and morphologic overlap between reactive and neoplastic lesions, as with non-fibrous lesions. In this article we describe and discuss four particular entities in some detail: fibromatosis of the breast, nodular fasciitis, pseudoangiomatous stromal hyperplasia of the breast and one case of mammary type myofibroblastoma. Read More
Semin Diagn Pathol 2004 Feb;21(1):57-64
Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.
Spindle cell lesions of the breast constitute a wide spectrum of benign and malignant proliferations. Myofibroblasts, normal cellular constituents of the mammary intra- and interlobular stroma, compose many of these lesions, which include reactive proliferations and benign or locally aggressive neoplasms. Because of its morphology, low-grade metaplastic spindle cell carcinoma, "fibromatosis-like" is also considered together with spindle cell lesions of the breast. Read More
Pathologica 2014 Jun;106(2):36-40
We report rare case of myofibroblastoma (MFB) of the breast comprised predominantly of a mature fatty component, representing approximately 70% of the entire tumour area. This tumour, designated "lipomatous MFB", should be interpreted as the morphological result of an unbalanced bidirectional differentiation of the precursor mammary stromal cell, with the adipocytic component overwhelming the fibroblastic/myofibroblastic one. Lipomatous MFB is a rare variant of mammary MFB, which can mimic malignancy because of the close juxtaposition of fibroblasts/myofibroblasts with mature adipocytes, resulting in a finger-like infiltrative growth pattern of the former towards the latter. Read More
Virchows Arch 2002 Mar 4;440(3):249-60. Epub 2002 Jan 4.
Istituto di Anatomia Patologica, Università di Catania, Via Biblioteca 4, 95124 Catania, Italy.
We reviewed the clinico-pathological features of a series of 13 cases of benign spindle stromal tumors (BSSTs) of the breast relating to a basic common theme consisting of a well-circumscribed proliferation of vimentin+/CD34+/BCL-2+/CD99+ spindly to oval-epithelioid cells, variably arranged in haphazard to short fascicular growth pattern, with interspersed thick or thin collagen bands. Morphological variations included atypical mono- or multi-nucleated cells in five cases and a mature lipomatous tumor component, varying from focal to prominent, in eight cases. Based on morphological and immunophenotypical features, a distinction was made between two main subtypes of these tumors--fibroblastic and myofibroblastic. Read More