The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens.

Cell Chem Biol 2017 Sep 20;24(9):1066-1074. Epub 2017 Jul 20.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

In the last decade we have witnessed tremendous advances in our understanding of the landscape of the molecular alterations that underpin many of the most prevalent cancers, in the use of automated high-throughput platforms for high-throughput drug screens in cancer cells, in the creation of more clinically relevant cancer cell models, and lastly in the development of more useful computational approaches in the pursuit of biomarkers of drug response. Separately, each of these improvements will undoubtedly lead to improvements in the treatment of cancer patients but to fulfill the promise of truly personalized cancer medicine, we must bring these disciplines together in a truly multidisciplinary fashion.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S24519456173022
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2017.06.011DOI Listing
September 2017
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