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    Insight into immunocytes infiltrations in polymorphous light eruption.
    Biotechnol Adv 2017 Nov 17;35(6):751-757. Epub 2017 Jul 17.
    Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming, Yunnan, China. Electronic address:
    Polymorphous light eruption (PLE) which is one of the most common photodermatoses has been demonstrated to be immune-mediated disorder. Resistance to UV-induced immunosuppression resulting from differential immune cells infiltration and cytokines secretion has been highlighted in the pathogenesis of PLE. In this study, we reviewed differential patterns of immune cells infiltrations and cytokines secretion that may contribute to PLE occurrence and development.

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    Differential expression of cytokines in UV-B-exposed skin of patients with polymorphous light eruption: correlation with Langerhans cell migration and immunosuppression.
    Arch Dermatol 2004 Mar;140(3):295-302
    Department of Dermatology, University Medical Center Utrecht, Utrecht.
    Background: Disturbances in UV-induced Langerhans cell migration and T helper (T(H)) 2 cell responses could be early steps in the pathogenesis of PLE.

    Objective: To establish whether UV-B exposure induces aberrant cytokine expression in the uninvolved skin of patients with polymorphous light eruption (PLE).

    Design: Immunohistochemical staining and comparison of microscopic sections of skin irradiated with 6 times the minimal dose of UV-B causing erythema and the unirradiated skin of patients with PLE and of healthy individuals. Read More
    Polymorphous light eruption.
    J Eur Acad Dermatol Venereol 2002 May;16(3):193-206
    Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital for Skin and Venereal Diseases, 5 Dragoumi Street, Kesariani 161 21, Athens, Greece.
    Polymorphous light eruption (PLE) is a common idiopathic photosensitivity disorder with an estimated prevalence of 10-20%. It is characterized by an intermittent skin reaction to ultraviolet (UV) radiation exposure, consisting of non-scarring pruritic erythematous papules, vesicles or plaques that develop on light-exposed skin. Despite the different morphology in different individuals, the eruption tends to have a monomorphous presentation in any single subject. Read More
    Decreased neutrophil skin infiltration after UVB exposure in patients with polymorphous light eruption.
    J Invest Dermatol 2004 Jul;123(1):202-6
    Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
    UV radiation, in particular UVB, suppresses the skin immune response. In patients with polymorphous light eruption (PLE) the skin immune response seems activated after UV exposure. Typical PLE skin lesions can occur as early as several hours after UV exposure. Read More
    Prevention of polymorphous light eruption and solar urticaria.
    Skin Therapy Lett 2002 Sep;7(7):3-5
    Division of Dermatology, University of Montreal Hospital Centre, Montreal, Quebec, Canada.
    Polymorphous light eruption (PLE) and solar urticaria (SU) are two photodermatoses that are induced by ultraviolet radiation and sometimes by visible light. This article will review the various means of preventing PLE and SU with an emphasis on the role of sunscreens. Read More