Biotechnol Adv 2017 Nov 17;35(6):751-757. Epub 2017 Jul 17.
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming, Yunnan, China. Electronic address:
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Arch Dermatol Res 2004 Oct 2;296(5):240-1. Epub 2004 Sep 2.
Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown by recent results, and it is hypothesized that in PLE patients, there is a partial failure of ultraviolet radiation-induced immunosuppression, causing an abnormal response to autologous antigens generated by ultraviolet radiation (UVR). Read More
J Invest Dermatol 2010 Nov 8;130(11):2578-82. Epub 2010 Jul 8.
Department of Dermatology, University of Turku, Turku, Finland.
Polymorphic light eruption (PLE) is a common skin disorder provoked by exposure to UVR. Its clinical symptoms resemble those of a contact allergic reaction. PLE is generally considered a T-cell-mediated autoimmune reaction toward a yet unidentified antigen formed in UVR-exposed skin. Read More
Br J Dermatol 2011 Jul;165(1):2-3
Department of Dermatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.
J Invest Dermatol 2004 Feb;122(2):291-4
Department of Dermatopharmacology, Southampton General Hospital, Southampton, UK.
It is hypothesized that polymorphic light eruption is characterized by a partial failure of ultraviolet radiation-induced immunosuppression, resulting in a delayed-type hypersensitivity response to photo-induced antigens. We aimed to study the susceptibility of PLE patients to UVR-induced immunosuppression, by measuring the strength of sensitization to 2,4-dinitrochlorobenzene after UVR exposure, and to diphenylcyclopropenone without UVR exposure, in subjects with PLE and controls. Thirteen PLE patients and 11 controls were exposed to 1 minimum erythema dose (MED) of UVR delivered from Waldmann UV-6 bulbs to the upper inner arm. Read More