Curr Opin Rheumatol 2017 Nov;29(6):553-560
Department of Medicine, University of California, David Geffen School of Medicine, California, Los Angeles, USA.
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Arthritis Rheumatol 2016 06;68(6):1483-92
University of California, Los Angeles David Geffen School of Medicine.
Objective: To compare colonic microbial composition in systemic sclerosis (SSc) patients and healthy controls and to determine whether certain microbial genera are associated with gastrointestinal (GI) tract symptoms in patients with SSc.
Methods: Healthy controls were age- and sex-matched (1:1) with adult SSc patients. Cecum and sigmoid mucosal lavage samples were obtained during colonoscopy. Read More
Microbiol Spectr 2015 Jun;3(3)
The healthy human intestine is colonized by as many as 1014 bacteria belonging to more than 500 different species forming a microbial ecosystem of unsurpassed diversity, termed the microbiota. The microbiota's various bacterial members engage in a physiological network of cooperation and competition within several layers of complexity. Within the last 10 years, technological progress in the field of next-generation sequencing technologies has tremendously advanced our understanding of the wide variety of physiological and pathological processes that are influenced by the commensal microbiota (1, 2). Read More
BMJ Open Gastroenterol 2017 1;4(1):e000134. Epub 2017 Apr 1.
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.
Objective: To compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts with controls and to determine whether certain genera are associated with SSc-gastrointestinal tract (GIT) symptoms.
Design: Adult patients with SSc from the University of California, Los Angeles (UCLA) and Oslo University Hospital (OUH) and healthy controls participated in this study (1:1:1). All participants provided stool specimens for 16S rRNA sequencing. Read More
Arthritis Res Ther 2016 11 29;18(1):278. Epub 2016 Nov 29.
Department of Clinical Sciences, Lund University, Lund, Sweden.
Background: Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate the prevalence of intestinal dysbiosis in SSc and to characterise patients suffering from this potentially immunomodulatory deviation.
Methods: This study consisted of 98 consecutive patients subject to in-hospital care. Read More