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Clin Neurol Neurosurg 2021 Feb 18;203:106565. Epub 2021 Feb 18.

Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA.

Background: Although spinal cord injury (SCI) is a major cause of disability, current therapeutic options remain limited. Recent progress in cellular therapy with mesenchymal stem cells (MSCs) has provided improved function in animal models of SCI. We investigated the safety and feasibility of intravenous infusion of MSCs for SCI patients and assessed functional status after MSC infusion. Read More

Biochim Biophys Acta Mol Basis Dis 2021 Mar 2:166117. Epub 2021 Mar 2.

Department of Physiology and Pathophysiology, Regenerative Medicine Program, Spinal Cord Research Centre, Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

White matter degeneration is an important pathophysiological event of the central nervous system that is collectively characterized by demyelination, oligodendrocyte loss, axonal degeneration and parenchymal changes that can result in sensory, motor, autonomic and cognitive impairments. White matter degeneration can occur due to a variety of causes including trauma, neurotoxic exposure, insufficient blood flow, neuroinflammation, and developmental and inherited neuropathies. Regardless of the etiology, the degeneration processes share similar pathologic features. Read More

Neurosci Lett 2021 Mar 2:135793. Epub 2021 Mar 2.

Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, 730000, China; Orthopaedics Key laboratory of Gansu Province, Lanzhou, Gansu, 730000, China. Electronic address:

Grape seed proanthocyanidins (GSP) are natural flavonoids with strong antioxidant and anti-apoptotic effects. Oxidative stress and neuronal apoptosis are major contributors to spinal cord injury (SCI). In this study, we assessed the potential protective effects of GSP on hydrogen peroxide (HO)-damaged pheochromocytoma-12 (PC12) cells in an in vitro model of SCI as well as the putative mechanism of action. Read More

Neuron 2021 Feb 24. Epub 2021 Feb 24.

UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal inflammation has not been determined. Guided by single-cell RNA sequencing (scRNA-seq), we found that MRC1 spinal cord macrophages proliferated and upregulated the anti-inflammatory mediator Cd163 in mice following superficial injury (SI; nerve intact), but this response was blunted in nerve-injured animals. Depleting spinal macrophages in SI animals promoted microgliosis and caused mechanical hypersensitivity to persist. Read More

J Trauma Nurs 2021 Apr-Jun 01;28(2):107-118

University of Kentucky College of Nursing, Lexington (Mss Silverstein and Henderson and Dr Higgins); and Department of Nursing Professional Practice and Support, UK HealthCare, Lexington, Kentucky (Dr Higgins).

Background: Following hospital discharge after traumatic injuries, many patients' rehabilitation is inhibited by poor health-related quality of life (HRQoL).

Objective: The purpose of this review is to identify factors that influence the HRQoL of polytrauma patients after hospital discharge.

Methods: A systematic literature search was performed in CINAHL and PubMed databases for English-language articles published between January 2015 and January 2020. Read More