Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Mr. Shahzad Ahmad, MSc
Mr. Shahzad Ahmad, MSc
Jamia Hamdard (Hamdard University)
Phd Student (Senior Research Fellow, UGC-BSR)
Endocrine Toxicology
New Delhi, Delhi | India
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10, odds ratio (OR) = 0.68, minor allele frequency (MAF) = 0.0059, MAF = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10, OR = 1.43, MAF = 0.011, MAF = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10, OR = 1.67, MAF = 0.0143, MAF = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017
200 Reads
58 Citations
29.352 Impact Factor

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
May 28, 2019, 1:03 pm EST
twitter
Twitter:
May 28, 2019, 8:47 am EST
twitter
Twitter:
May 28, 2019, 3:47 am EST
twitter
Twitter:
May 28, 2019, 3:45 am EST
twitter
Twitter:
May 28, 2019, 3:15 am EST
twitter
Twitter:
May 27, 2019, 5:01 pm EST
twitter
Twitter:
May 27, 2019, 8:48 am EST
twitter
Twitter:
April 28, 2019, 1:36 am EST
twitter
Twitter: Ch_douse
April 27, 2018, 2:46 pm EST
wikipedia
Wikipedia: Talk:Alzheimer's disease
February 18, 2018, 11:57 am EST
twitter
Twitter: Dayleparker_
October 1, 2017, 8:16 pm EST
twitter
Twitter: Kapoormanav
September 23, 2017, 6:13 pm EST
twitter
Twitter: IShabam
September 23, 2017, 1:58 am EST
twitter
Twitter: Cbulik
September 23, 2017, 1:57 am EST
twitter
Twitter: PGCgenetics
September 22, 2017, 4:58 pm EST
twitter
Twitter: Aapb_argentina
September 22, 2017, 4:43 pm EST
twitter
Twitter: Aapb_argentina
September 22, 2017, 4:42 pm EST
twitter
Twitter: Yang_bio
September 22, 2017, 1:18 pm EST
twitter
Twitter: SomercoResearch
September 22, 2017, 11:31 am EST
twitter
Twitter: AWargelius
September 22, 2017, 9:35 am EST
twitter
Twitter: APredeus
September 22, 2017, 7:32 am EST
twitter
Twitter: Leorange69
September 22, 2017, 6:26 am EST
twitter
Twitter: Kappissima
September 22, 2017, 5:32 am EST
twitter
Twitter: Naveedkashmiri
September 22, 2017, 4:15 am EST
twitter
Twitter: Raguirre_g
September 22, 2017, 4:07 am EST
twitter
Twitter: GenomeBiology
September 22, 2017, 4:03 am EST
twitter
Twitter: Lisanwang
September 21, 2017, 8:36 pm EST
twitter
Twitter: Morri_maurizio
September 21, 2017, 8:13 pm EST
twitter
Twitter: Josefra1975
September 21, 2017, 1:42 pm EST
twitter
Twitter: SImbeaud
September 21, 2017, 1:08 pm EST
twitter
Twitter: NutriGenome
September 21, 2017, 12:07 pm EST
twitter
Twitter: Pbezzi69
September 21, 2017, 11:52 am EST
twitter
Twitter: PharmaDecisions
September 21, 2017, 10:40 am EST
twitter
Twitter: Jewegener
September 21, 2017, 9:45 am EST
twitter
Twitter: Mati_madii
September 21, 2017, 9:37 am EST
twitter
Twitter: DukeMGM
September 21, 2017, 9:26 am EST
twitter
Twitter: NatureGenet
September 21, 2017, 9:25 am EST
twitter
Twitter: ISD_Research
September 19, 2017, 4:54 am EST
twitter
Twitter: Mpbarrouillet
September 13, 2017, 8:36 am EST
twitter
Twitter: IShare_etude
September 13, 2017, 8:03 am EST
twitter
Twitter: Visitor_z
September 5, 2017, 11:55 pm EST
twitter
Twitter: SergylB
August 31, 2017, 1:33 pm EST
twitter
Twitter: Prof_Farmacia
August 31, 2017, 11:04 am EST
twitter
Twitter: TheWhatIFPlan
August 30, 2017, 3:20 pm EST
twitter
Twitter: Aquarius1768
August 30, 2017, 2:19 pm EST
twitter
Twitter: Bakermind
August 30, 2017, 1:53 pm EST
twitter
Twitter: Whsource
August 30, 2017, 1:45 pm EST
twitter
Twitter: MDBiosciences
August 24, 2017, 3:07 pm EST
twitter
Twitter: JuliaEdgar1
August 22, 2017, 3:52 pm EST
twitter
Twitter: Pathowitter
August 21, 2017, 9:01 pm EST
twitter
Twitter: CyborgSnuggles
August 21, 2017, 3:07 pm EST
twitter
Twitter: JMannisi
August 18, 2017, 12:38 am EST
twitter
Twitter: Prof_Farmacia
August 17, 2017, 7:32 am EST
twitter
Twitter: MedItOnline
August 9, 2017, 10:00 am EST
twitter
Twitter: Aakasharmand
August 7, 2017, 1:19 pm EST
twitter
Twitter: PennPathLabMed
August 7, 2017, 11:35 am EST
twitter
Twitter: IDIVALdecilla
August 7, 2017, 2:44 am EST
twitter
Twitter: Karenleekale
August 6, 2017, 5:31 pm EST
twitter
Twitter: Jamessodabi
August 3, 2017, 5:22 pm EST
twitter
Twitter: AlzheimerGenes
July 30, 2017, 11:51 am EST
twitter
Twitter: AlzheimerGenes
July 30, 2017, 11:50 am EST
twitter
Twitter: Greenheartsinfo
July 27, 2017, 7:36 pm EST
twitter
Twitter: Jjkelleyiii
July 27, 2017, 6:22 pm EST
twitter
Twitter: Autismepi
July 27, 2017, 1:30 pm EST
twitter
Twitter: Dr_shibley
July 27, 2017, 1:21 pm EST
twitter
Twitter: Cyndig1Cynthia
July 27, 2017, 1:17 pm EST
twitter
Twitter: And_kell
July 27, 2017, 12:46 pm EST
twitter
Twitter: Katiewr31413491
July 27, 2017, 11:19 am EST
twitter
Twitter: Supergecko
July 27, 2017, 9:58 am EST
twitter
Twitter: Jamessodabi
July 26, 2017, 9:30 pm EST
twitter
Twitter: BCM_HGSC
July 26, 2017, 11:11 am EST
twitter
Twitter: PepeRodriguez44
July 25, 2017, 1:20 pm EST
twitter
Twitter: DrNatalieACope
July 24, 2017, 3:24 pm EST
twitter
Twitter: Yogysaby
July 24, 2017, 1:30 am EST
twitter
Twitter: Mlambrecht
July 23, 2017, 6:32 am EST
twitter
Twitter: Mathvsoldage
July 23, 2017, 1:18 am EST
twitter
Twitter: Drbachinsky
July 23, 2017, 1:18 am EST
twitter
Twitter: KangMSPeter
July 22, 2017, 4:56 pm EST
twitter
Twitter: Tekraynak
July 22, 2017, 11:26 am EST
twitter
Twitter: DrDavidPearce
July 22, 2017, 3:52 am EST
twitter
Twitter: Caffeinatedcee
July 22, 2017, 1:45 am EST
twitter
Twitter: Microbedr
July 21, 2017, 9:24 pm EST
twitter
Twitter: Bloodgenes
July 21, 2017, 9:10 pm EST
twitter
Twitter: Piwdb
July 21, 2017, 9:08 pm EST
twitter
Twitter: FarwaAli_
July 21, 2017, 8:55 pm EST
twitter
Twitter: IParkkinen
July 21, 2017, 4:46 pm EST
twitter
Twitter: LorenzaMagnoPhD
July 21, 2017, 4:31 pm EST
twitter
Twitter: Yusuchn
July 21, 2017, 4:24 pm EST
twitter
Twitter: Scapuzzi_unc
July 21, 2017, 3:37 pm EST
twitter
Twitter: SusanTaylorSD
July 21, 2017, 2:07 pm EST
twitter
Twitter: Eric_Chevet
July 21, 2017, 1:55 pm EST
twitter
Twitter: NeuroGeneticus
July 21, 2017, 1:01 pm EST
twitter
Twitter: Ebethsypek
July 21, 2017, 12:55 pm EST
twitter
Twitter: Chemabelloso
July 21, 2017, 12:41 pm EST
twitter
Twitter: Berkeleyprc
July 21, 2017, 12:05 pm EST
twitter
Twitter: Dheerajroy7
July 21, 2017, 11:56 am EST
twitter
Twitter: 1RabP
July 21, 2017, 11:31 am EST
twitter
Twitter: Antonioligi_nov
July 21, 2017, 11:13 am EST
twitter
Twitter: WiringTheBrain
July 21, 2017, 10:58 am EST
twitter
Twitter: Dereklowe
July 21, 2017, 10:14 am EST
twitter
Twitter: AFPopgen
July 21, 2017, 10:06 am EST
twitter
Twitter: Iniesta_mpador
July 21, 2017, 9:50 am EST
twitter
Twitter: DynamicMutation
July 21, 2017, 9:40 am EST
twitter
Twitter: NatureGenet
July 21, 2017, 9:40 am EST
twitter
Twitter: DynamicMutation
July 21, 2017, 9:40 am EST
twitter
Twitter: Jaybradner
July 21, 2017, 9:03 am EST
twitter
Twitter: CharlestonCWKC
July 19, 2017, 6:56 pm EST
twitter
Twitter: Drjameswalters
July 18, 2017, 2:29 am EST
twitter
Twitter: Waweru
July 18, 2017, 12:24 am EST
twitter
Twitter: Yon_wahyu
July 17, 2017, 7:55 pm EST
twitter
Twitter: GangFighterKy2
July 17, 2017, 7:39 pm EST
twitter
Twitter: EleonorPauwels
July 17, 2017, 7:26 pm EST
twitter
Twitter: StemCellPilot
July 17, 2017, 6:02 pm EST
twitter
Twitter: Cara_Croft
July 17, 2017, 5:50 pm EST
twitter
Twitter: ALEscamez
July 17, 2017, 5:32 pm EST
twitter
Twitter: DervisSalih1
July 17, 2017, 5:32 pm EST
twitter
Twitter: Westr
July 17, 2017, 5:30 pm EST
twitter
Twitter: ALEscamez
July 17, 2017, 5:29 pm EST
twitter
Twitter: SirSharpest
July 17, 2017, 5:08 pm EST
twitter
Twitter: SilverVVulpes
July 17, 2017, 4:58 pm EST
twitter
Twitter: ElementoLab
July 17, 2017, 4:30 pm EST
twitter
Twitter: Greekgenomic23
July 17, 2017, 4:18 pm EST
twitter
Twitter: IParkkinen
July 17, 2017, 3:40 pm EST
twitter
Twitter: Datadriveby
July 17, 2017, 3:10 pm EST
twitter
Twitter: Harpreet_ksaini
July 17, 2017, 3:10 pm EST
twitter
Twitter: Fararod
July 17, 2017, 2:43 pm EST
twitter
Twitter: DrRobertGlatter
July 17, 2017, 2:20 pm EST
twitter
Twitter: JMannisi
July 17, 2017, 2:13 pm EST
twitter
Twitter: Kasper_lage
July 17, 2017, 1:53 pm EST
twitter
Twitter: Rss_sarah
July 17, 2017, 1:46 pm EST
twitter
Twitter: Q_StatGen
July 17, 2017, 1:44 pm EST
twitter
Twitter: Cdeboever3
July 17, 2017, 1:37 pm EST
twitter
Twitter: Lashleywatson
July 17, 2017, 1:36 pm EST
twitter
Twitter: Obahcall
July 17, 2017, 1:33 pm EST
twitter
Twitter: Uri713
July 17, 2017, 1:31 pm EST
twitter
Twitter: Faturrrrachman
July 17, 2017, 1:17 pm EST
twitter
Twitter: Mabasalamah
July 17, 2017, 1:04 pm EST
twitter
Twitter: Bastakif
July 17, 2017, 1:03 pm EST
twitter
Twitter: Jsantoyo
July 17, 2017, 12:59 pm EST
twitter
Twitter: Nmckeehan
July 17, 2017, 12:39 pm EST
twitter
Twitter: NeuroMinded
July 17, 2017, 12:37 pm EST
twitter
Twitter: Sengupso
July 17, 2017, 12:35 pm EST
twitter
Twitter: AlyssaBohnert
July 17, 2017, 12:35 pm EST
twitter
Twitter: MDBiosciences
July 17, 2017, 12:34 pm EST
twitter
Twitter: Naifalmontashir
July 17, 2017, 12:34 pm EST
twitter
Twitter: NatureGenet
July 17, 2017, 12:30 pm EST
twitter
Twitter: Cathcoste
July 17, 2017, 12:30 pm EST
twitter
Twitter: IzzyMoorePhD
July 17, 2017, 12:21 pm EST
twitter
Twitter: PharmaDecisions
July 17, 2017, 12:04 pm EST
twitter
Twitter: Gelantonia
July 17, 2017, 11:57 am EST
twitter
Twitter: TAFORU
July 17, 2017, 11:57 am EST
twitter
Twitter: InJusticeThBook
July 17, 2017, 11:57 am EST
twitter
Twitter: Guidodavidzon
July 17, 2017, 11:55 am EST
twitter
Twitter: Michaelscally
July 17, 2017, 11:55 am EST
twitter
Twitter: Elsaid98Sameh
July 17, 2017, 11:54 am EST
twitter
Twitter: EricTopol
July 17, 2017, 11:53 am EST
twitter
Twitter: Beccy_sims
July 17, 2017, 11:07 am EST
twitter
Twitter: George489
July 17, 2017, 11:07 am EST

Publication Analysis

Top Keywords

alzheimer's disease
24
variants associated
8
associated alzheimer's
8
coding variants
8
rare coding
8
imputed genotypes
8
alzheimer's
6
maf
6
disease
6
interaction network
4
odds ratio
4
ratio 068
4
538 odds
4
disease protein-altering
4
ppro522arg 538
4
associations imputed
4
068 minor
4
protein-protein interaction
4
immune-related protein-protein
4
maf 00059
4

References

(Supplied by CrossRef)
Article in Arch. Gen. Psychiatry
M Gatz et al.
Arch. Gen. Psychiatry 2006
Article in Nat. Genet.
J-C Lambert et al.
Nat. Genet. 2013
Article in Nat. Genet.
D Harold et al.
Nat. Genet. 2009
Article in Nat. Genet.
J-C Lambert et al.
Nat. Genet. 2009
Article in PLoS One
V Escott-Price et al.
PLoS One 2014
Article in Nat. Genet.
P Hollingworth et al.
Nat. Genet. 2011
Article in Nat. Genet.
AC Naj et al.
Nat. Genet. 2011
Article in Alzheimers Dement.
A Ruiz et al.
Alzheimers Dement. 2014
Article in N. Engl. J. Med.
T Jonsson et al.
N. Engl. J. Med. 2013
Article in Nature
T Jonsson et al.
Nature 2012
Article in N. Engl. J. Med.
R Guerreiro et al.
N. Engl. J. Med. 2013

Similar Publications