Asian J Psychiatr 2017 Dec 8;30:31-32. Epub 2017 Jul 8.
Department of Psychiatry, Government TD Medical College, Alappuzha, Kerala, 688005, India. Electronic address:
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Oncoimmunology 2018 21;7(3):e1405205. Epub 2017 Dec 21.
Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.
Immunotherapy has expanded treatment options for cancers with historically poor outcomes, yet a significant proportion of patients still fail to achieve durable clinical benefit. We defined the contribution of β-adrenergic receptor (βAR) signaling, a component of the stress response, on success of immunotherapy for melanoma since the use of antagonists (β-blockers) is associated with improved clinical outcomes in some cancers. We show that metastatic melanoma patients who received immunotherapy had improved overall survival if they also received pan β-blockers. Read More
F1000Res 2017 20;6:2153. Epub 2017 Dec 20.
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.
Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety profile in a wide range of animal models and human clinical trials. With the advent of clustered regulatory interspaced short palindromic repeat (CRISPR)-based genome-editing technologies, AAV provides one of the most suitable viral vectors to package, deliver, and express CRISPR components for targeted gene editing. Recent discoveries of smaller Cas9 orthologues have enabled the packaging of Cas9 nuclease and its chimeric guide RNA into a single AAV delivery vehicle for robust genome editing. Read More
Environ Pollut 2017 Nov 7;230:495-505. Epub 2017 Jul 7.
Global Centre for Environmental Remediation, University of Newcastle, Australia.
Derelict mines pose potential risks to environmental health. Several factors such as soil structure, organic matter, and nutrient content are the greatly affected qualities in mined soils. Soil microbial communities are an important element for successful reclamation because of their major role in nutrient cycling, plant establishment, geochemical transformations, and soil formation. Read More
J Cell Sci 2017 01 21;130(1):278-291. Epub 2016 Jul 21.
Electron Microscopy Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK
The processes of life take place in multiple dimensions, but imaging these processes in even three dimensions is challenging. Here, we describe a workflow for 3D correlative light and electron microscopy (CLEM) of cell monolayers using fluorescence microscopy to identify and follow biological events, combined with serial blockface scanning electron microscopy to analyse the underlying ultrastructure. The workflow encompasses all steps from cell culture to sample processing, imaging strategy, and 3D image processing and analysis. Read More
J Commun Dis 2008 Sep;40(3):205-10
Department, Community Medicine, Calcutta National Medical College, 32 Gorachand Road, Kolkata-760 014.
Dengue is one of the major public health problems which can be controlled with active participation of the community. A cross sectional study was conducted in urban field practice area of Calcutta National Medical College to determine perception of general population on the disease Dengue. A total 161 individuals were interviewed regarding the different aspects of the Dengue fever. Read More